Relationship between Two Blood Stasis Syndromes and Inflammatory Factors in Patients with Acute Coronary Syndrome

• Published in: Chinese journal of integrative medicine Vol. 23; no. 11; pp. 845 - 849
• Main Authors: Ma, Cai-yun, Liu, Jing-hua, Liu, Jian-xun, Shi, Da-zhuo, Xu, Zhen-ye, Wang, Shao-ping, Jia, Min, Zhao, Fu-hai, Jiang, Yue-rong, Ma, Qin, Peng, Hong-yu, Lu, Yuan, Zheng, Ze, Ren, Feng-xue
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2017
• Subjects: Acute Coronary Syndrome - blood; Acute Coronary Syndrome - diagnostic imaging; Coronary Angiography; Female; Humans; ICAM-1; Inflammation - blood; Inflammation Mediators - metabolism; Male; Medicine; Medicine & Public Health; Middle Aged; Original Article; Syndrome; 冠状动脉造影; 因子和; 急性冠状动脉综合征; 急性冠脉综合征; 气虚血瘀证; 炎症因子; 细胞间黏附分子-1; Chinese medicine; chitinase-3-like protein 1; inflammation; qi stagnation and blood stasis syndrome; intracellular adhesion molecule-1; coronary heart disease; lipoprotein-associated phospholipase A2; qi deficiency and blood stasis syndrome
• ISSN: 1672-0415; 1993-0402
• DOI: 10.1007/s11655-016-2746-0

Objective： To investigate the relationship between inflammatory factors and two Chinese medicine（CM） syndrome types of qi stagnation and blood stasis（QSBS） and qi deficiency and blood stasis（QDBS） in patients with acute coronary syndrome（ACS）. Methods： Sixty subjects with ACS, whose pathogenesis changes belongs to qi disturbance blood stasis syndrome, were divided into 2 groups： 30 in the QSBS group and 30 in the QDBS group. The comparative analysis on them was carried out through comparing general information, coronary angiography and inflammatory factors including intracellular adhesion molecule-1（ICAM-1）, chitinase-3-like protein 1（YKL-40） and lipoprotein-associated phospholipase A2（Lp-PLA2）. Results： Compared with the QSBS group, Lp-PLA2 and YKL-40 levels in the QDBS group showed no-significant difference（P〉0.05）; ICAM-1 was significantly higher in the QDBS group than in the QSBS group in the pathological processes of qi disturbance and blood stasis syndrome of ACS（P〈0.05）. Conclusion： Inflammatory factor ICAM-1 may be an objective basis for syndrome typing of QSBS and QDBS, which provides a research direction for standardization research of CM syndrome types.