The Influence of HIV Status on the Burden and Clinical Manifestations of Gastrointestinal Pathogens in Yangon, Myanmar

The impact of HIV infection on the burden of gastrointestinal pathogens in Myanmar is poorly defined. Stools of 103 HIV-infected and 105 HIV-uninfected adult outpatients at a tertiary referral hospital in Yangon were examined microscopically. Stool antigen tests for infection were positive in 63/103...

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Published inThe American journal of tropical medicine and hygiene Vol. 102; no. 4; pp. 884 - 888
Main Authors Pa Pa Aung, Win, Myint, Nan Phyu Sin Toe, Zaw, Thet Tun, Cooper, David A, Aung, Ne Myo, Kyi, Mar Mar, Lwin, Mya Mya, Hanson, Josh
Format Journal Article
LanguageEnglish
Published United States Institute of Tropical Medicine 01.04.2020
The American Society of Tropical Medicine and Hygiene
Subjects
Adult
Digestive system
Feces - parasitology
Female
Gastrointestinal Diseases - complications
Gastrointestinal Diseases - epidemiology
Health risk assessment
HIV
HIV Infections - complications
HIV Infections - epidemiology
Human immunodeficiency virus
Humans
Infections
Male
Middle Aged
Myanmar - epidemiology
Parasitic diseases
Parasitic Diseases - complications
Parasitic Diseases - epidemiology
Parasitic Diseases - parasitology
Pathogens
Myanmar
Yangon Myanmar
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Summary:The impact of HIV infection on the burden of gastrointestinal pathogens in Myanmar is poorly defined. Stools of 103 HIV-infected and 105 HIV-uninfected adult outpatients at a tertiary referral hospital in Yangon were examined microscopically. Stool antigen tests for infection were positive in 63/103 (61%) HIV-infected and 61/105 (58%) HIV-uninfected patients ( = 0.65). Soil-transmitted helminth infections were much less common, occurring in 9/103 (9%) HIV-infected and 13/103 (13%) HIV-uninfected patients ( = 0.50). One HIV-uninfected patient had , but there were no cases of , , , , , or infection in the entire cohort. Despite the high prevalence of , only 1/208 (0.5%) had ever received eradication, compared with 159/208 (76%) who had ever been dewormed. appears to be an underappreciated pathogen in Myanmar. Its strong association with gastric cancer and peptic ulcer disease necessitates a more aggressive approach to its management.
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Disclosures: The stool antigen tests used in the study were provided at a discounted price by BioMérieux.
These authors contributed equally to the work.
Professor David Cooper has sadly passed away during the preparation of this report, but contributed significantly to the work.
Authors’ addresses: Win Pa Pa Aung and Mya Mya Lwin, Department of Microbiology, University of Medicine 2, Yangon, Myanmar, E-mails: eipamicro@gmail.com and mmlwindr@gmail.com. Nan Phyu Sin Toe Myint, Department of Microbiology, University of Medicine 2, Yangon, Myanmar, and Medicine, Insein General Hospital, Yangon, Myanmar, E-mail: phyujasmine23@gmail.comm. Thet Tun Zaw and Mar Mar Kyi, Medicine, Insein General Hospital, Yangon, Myanmar, E-mails: thattunzaw1995.tz@gmail.com and drmmkyi@gmail.com. David A. Cooper, The Director’s Unit, The Kirby Institute, Sydney, Australia, E-mail: dcooper@kirby.unsw.edu.au. Ne Myo Aung, Department of Medicine, University of Medicine 2, Yangon, Myanmar, E-mail: drnaymyoaung@gmail.com. Josh Hanson, The Director’s Unit, The Kirby Institute, University of New South Wales, Sydney, Australia, and General Medicine, Cairns Hospital, Cairns, Australia, E-mail: jhanson@kirby.unsw.edu.au.
ISSN:0002-9637
1476-1645
DOI:10.4269/ajtmh.19-0725