Glycan microarrays: new angles and new strategies

Carbohydrate microarrays, comprising hundreds to thousands of different glycan structures on solid surfaces in a spatially discrete pattern, are sensitive and versatile tools for the analysis of glycosylation changes in complex biological samples. Glycoarrays are also suitable for monitoring multipl...

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Bibliographic Details
Published inAnalyst (London) Vol. 139; no. 11; pp. 265 - 2657
Main Authors Donczo, Boglarka, Kerekgyarto, Janos, Szurmai, Zoltan, Guttman, Andras
Format Journal Article
LanguageEnglish
Published England 07.06.2014
Subjects
Communicable Diseases - physiopathology
Humans
Polysaccharides - chemistry
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Summary:Carbohydrate microarrays, comprising hundreds to thousands of different glycan structures on solid surfaces in a spatially discrete pattern, are sensitive and versatile tools for the analysis of glycosylation changes in complex biological samples. Glycoarrays are also suitable for monitoring multiple molecular interactions with biomolecules where sugars are involved, offering a large variety of bioassay options. In this paper we review the most important glycan microarray types currently used with their main applications, and discuss some of the future challenges the technology faces. Review of the most important glycan microarray types currently used, their main applications, and future challenges that the technology faces.
Bibliography:ObjectType-Article-2
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ISSN:0003-2654
1364-5528
DOI:10.1039/c3an02289g