Synthesis of ceramic-polymer-drug biocomposites at room temperature

The preparation of hard composites by the free radical polymerization at room temperature of a blend of β-tricalcium phosphate, poly(ethyl methacrylate), methyl methacrylate monomer and fosfosal ® is described. After the immersion of the composites in a buffered solution, the controlled release of a...

Full description

Saved in:
Bibliographic Details
Published inSolid state ionics Vol. 101; no. pt 2; pp. 887 - 892
Main Authors Vallet-Regí, M., Gordo, M., Ragel, C.V., Cabañas, M.Y., Román, J.San
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.11.1997
Subjects
Biocomposites
Ceramic materials
Ceramic-drug complex
Controlled drug delivery
Drug products
Drug release
Fourier transform infrared spectroscopy
Free radical polymerization
Monomers
Polymer blends
Polymerization at room temperature
Polymethyl methacrylates
Synthesis (chemical)
Drug release
Polymerization at room temperature
Ceramic-drug complex
β-Tricalcium phosphate
Poly(ethyl methacrylate)
Methyl methacrylate
Biocomposites
Fosfosal
Online AccessGet full text

Cover

Abstract The preparation of hard composites by the free radical polymerization at room temperature of a blend of β-tricalcium phosphate, poly(ethyl methacrylate), methyl methacrylate monomer and fosfosal ® is described. After the immersion of the composites in a buffered solution, the controlled release of an analgesic drug, fosfosal, is observed. The ceramic component participates actively in the control of the release of the drug by means of the formation of a bridging complex with the fosfosal, as demonstrated by FTIR studies.
AbstractList The preparation of hard composites by the free radical polymerization at room temperature of a blend of beta -tricalcium phosphate, poly(ethyl methacrylate), methyl methacrylate monomer and fosfosal is described. After the immersion of the composites in a buffered solution, the controlled release of an analgesic drug, fosfosal, is observed. The ceramic component participates actively in the control of the release of the drug by means of the formation of a bridging complex with the fosfosal, as demonstrated by FTIR studies.
The preparation of hard composites by the free radical polymerization at room temperature of a blend of β-tricalcium phosphate, poly(ethyl methacrylate), methyl methacrylate monomer and fosfosal ® is described. After the immersion of the composites in a buffered solution, the controlled release of an analgesic drug, fosfosal, is observed. The ceramic component participates actively in the control of the release of the drug by means of the formation of a bridging complex with the fosfosal, as demonstrated by FTIR studies.
Author Cabañas, M.Y.
Román, J.San
Gordo, M.
Ragel, C.V.
Vallet-Regí, M.
Author_xml – sequence: 1
  givenname: M.
  surname: Vallet-Regí
  fullname: Vallet-Regí, M.
  email: vallet@eucmax.sim.ucm.es
  organization: Dpto. Química Inorgánica y Bioinorgánica, Facultad de Farmacia, UCM, 28040 Madrid, Spain
– sequence: 2
  givenname: M.
  surname: Gordo
  fullname: Gordo, M.
  organization: Dpto. Química Inorgánica y Bioinorgánica, Facultad de Farmacia, UCM, 28040 Madrid, Spain
– sequence: 3
  givenname: C.V.
  surname: Ragel
  fullname: Ragel, C.V.
  organization: Dpto. Química Inorgánica y Bioinorgánica, Facultad de Farmacia, UCM, 28040 Madrid, Spain
– sequence: 4
  givenname: M.Y.
  surname: Cabañas
  fullname: Cabañas, M.Y.
  organization: Dpto. Química Inorgánica y Bioinorgánica, Facultad de Farmacia, UCM, 28040 Madrid, Spain
– sequence: 5
  givenname: J.San
  surname: Román
  fullname: Román, J.San
  organization: Dpto. Química Inorgánica y Bioinorgánica, Facultad de Farmacia, UCM, 28040 Madrid, Spain
BookMark eNqFkE1LAzEQhoNUsK3-BGFPoodoZuPm4yRS_IKCh-o5pNlZjXQ3a7Ir9N-724rXXmbm8LwPzDsjkyY0SMg5sGtgIG5Ww5A0l1xdannFWA6awhGZgpI5lULpCZn-IydkltIXY0xwJaZksdo23Scmn7JQZQ6jrb2jbdhsa4y0jP1HtvbBhboNyXeYMttlMYQ667BuB7rrI56S48puEp797Tl5f3x4WzzT5evTy-J-SR2X0NG8YKyweriFRmFVZR1za64qJThyqGwB1nHAgoOubhGgZIDO5uh0JUQJfE4u9t42hu8eU2dqnxxuNrbB0CczvCeLXIrDIORaimI0FnvQxZBSxMq00dc2bg0wM3Zrdt2OZmW0NLtuzZi72-dwePfHYzTJeWwclj6i60wZ_AHDL8lJgzI
CitedBy_id crossref_primary_10_1002_ejic_200390134
crossref_primary_10_1002_zaac_200700278
crossref_primary_10_13168_cs_2024_0004
crossref_primary_10_1002_jbm_a_31867
crossref_primary_10_1021_cm031074n
crossref_primary_10_1016_j_jconrel_2004_04_023
crossref_primary_10_1016_j_clay_2012_10_014
crossref_primary_10_1016_j_biomaterials_2003_09_004
crossref_primary_10_1016_j_mtchem_2019_100230
crossref_primary_10_1016_j_biomaterials_2004_09_018
ContentType Journal Article
Copyright 1997
Copyright_xml – notice: 1997
DBID AAYXX
CITATION
7SP
7U5
8FD
L7M
DOI 10.1016/S0167-2738(97)00219-1
DatabaseName CrossRef
Electronics & Communications Abstracts
Solid State and Superconductivity Abstracts
Technology Research Database
Advanced Technologies Database with Aerospace
DatabaseTitle CrossRef
Solid State and Superconductivity Abstracts
Technology Research Database
Advanced Technologies Database with Aerospace
Electronics & Communications Abstracts
DatabaseTitleList

Solid State and Superconductivity Abstracts
DeliveryMethod fulltext_linktorsrc
Discipline Physics
EISSN 1872-7689
EndPage 892
ExternalDocumentID 316488
10_1016_S0167_2738_97_00219_1
S0167273897002191
GroupedDBID --K
--M
.~1
0R~
123
1B1
1RT
1~.
1~5
4.4
457
4G.
5VS
6TJ
7-5
71M
8P~
9JN
AABNK
AABXZ
AACTN
AAEDT
AAEDW
AAEPC
AAHCO
AAIAV
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AAQXK
AARJD
AARLI
AAXUO
ABDEX
ABFNM
ABJNI
ABMAC
ABNEU
ABXDB
ABXRA
ABYKQ
ACDAQ
ACFVG
ACGFS
ACNNM
ACRLP
ADBBV
ADECG
ADEZE
ADIYS
ADMUD
AEBSH
AEKER
AENEX
AEZYN
AFFNX
AFKWA
AFRZQ
AFTJW
AFZHZ
AGHFR
AGUBO
AGYEJ
AHHHB
AHIDL
AIEXJ
AIKHN
AITUG
AIVDX
AJBFU
AJOXV
AJSZI
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
ASPBG
AVWKF
AXJTR
AZFZN
BBWZM
BELTK
BKOJK
BLXMC
CS3
DU5
EBS
EFJIC
EFLBG
EJD
EO8
EO9
EP2
EP3
FDB
FEDTE
FGOYB
FIRID
FLBIZ
FNPLU
FYGXN
G-2
G-Q
GBLVA
HMV
HVGLF
HZ~
IHE
J1W
JARJE
KOM
LY6
M24
M38
M41
MAGPM
MO0
N9A
NDZJH
O-L
O9-
OAUVE
OGIMB
OZT
P-8
P-9
P2P
PC.
Q38
R2-
RIG
RNS
ROL
RPZ
SAC
SCB
SDF
SDG
SDP
SES
SEW
SMS
SPC
SPCBC
SPD
SPG
SSK
SSM
SSQ
SSR
SSZ
T5K
WUQ
XPP
ZMT
ZU3
~02
~G-
AAXKI
AAYXX
AFJKZ
AKRWK
CITATION
7SP
7U5
8FD
L7M
ID FETCH-LOGICAL-c371t-25005a937169e6a8fac0cb38f863e31fa51ac31e5319f4e11d01eca2ec9f66d13
IEDL.DBID .~1
ISSN 0167-2738
IngestDate Fri Oct 25 21:39:20 EDT 2024
Fri Oct 25 09:23:16 EDT 2024
Thu Sep 26 15:27:39 EDT 2024
Fri Feb 23 02:19:20 EST 2024
IsPeerReviewed true
IsScholarly true
Issue pt 2
Keywords Drug release
Polymerization at room temperature
Ceramic-drug complex
β-Tricalcium phosphate
Poly(ethyl methacrylate)
Methyl methacrylate
Biocomposites
Fosfosal
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c371t-25005a937169e6a8fac0cb38f863e31fa51ac31e5319f4e11d01eca2ec9f66d13
Notes ObjectType-Article-2
SourceType-Scholarly Journals-2
ObjectType-Feature-1
content type line 23
SourceType-Conference Papers & Proceedings-1
ObjectType-Conference-3
ObjectType-Feature-2
ObjectType-Conference Paper-1
ObjectType-Article-3
PQID 21297651
PQPubID 23462
PageCount 6
ParticipantIDs proquest_miscellaneous_27375276
proquest_miscellaneous_21297651
crossref_primary_10_1016_S0167_2738_97_00219_1
elsevier_sciencedirect_doi_10_1016_S0167_2738_97_00219_1
PublicationCentury 1900
PublicationDate 1997-11-01
PublicationDateYYYYMMDD 1997-11-01
PublicationDate_xml – month: 11
  year: 1997
  text: 1997-11-01
  day: 01
PublicationDecade 1990
PublicationTitle Solid state ionics
PublicationYear 1997
Publisher Elsevier B.V
Publisher_xml – name: Elsevier B.V
References Nicholson, Anstice (BIB4) 1994; 2
Bowen, Argentar (BIB11) 1973; 17
Herbert (BIB13) 1993
Shima, Keller, Alvira (BIB7) 1979; 51
Venhoven, de Gee, Werner, Davidson (BIB2) 1994; 15
Hench (BIB1) 1991; 208
Ko (BIB3) 1989; 3
Park (BIB5) 1995
Constantino, Friedman (BIB8) 1994; 27
Jarcho, Salsbury, Thomas, Doremus (BIB6) 1979; 14
Elvira, Levenfe, Vázquez, Román (BIB9) 1996; 34
Román (BIB10) 1990; 413
Nakamoto (BIB14) 1986
(BIB12) 1986
References_xml – volume: 34
  start-page: 00
  year: 1996
  ident: BIB9
  publication-title: J. Polim. Sci. A: Polym. Chem.
  contributor:
    fullname: Román
– volume: 3
  start-page: 401
  year: 1989
  ident: BIB3
  publication-title: Ceram. Bull.
  contributor:
    fullname: Ko
– start-page: 82
  year: 1986
  end-page: 88
  ident: BIB12
  publication-title: Standard Specification for acrylic bone cement
– year: 1993
  ident: BIB13
  publication-title: NMR Spectroscopy of Polymers
  contributor:
    fullname: Herbert
– volume: 14
  start-page: 142
  year: 1979
  ident: BIB6
  publication-title: J. Mater. Sci.
  contributor:
    fullname: Doremus
– volume: 15
  start-page: 1152
  year: 1994
  ident: BIB2
  publication-title: Biomaterials
  contributor:
    fullname: Davidson
– volume: 17
  start-page: 2213
  year: 1973
  ident: BIB11
  publication-title: J. Appl. Polym. Sci.
  contributor:
    fullname: Argentar
– volume: 208
  start-page: 826
  year: 1991
  ident: BIB1
  publication-title: Science
  contributor:
    fullname: Hench
– volume: 51
  start-page: 533
  year: 1979
  ident: BIB7
  publication-title: J. Neurosurg.
  contributor:
    fullname: Alvira
– volume: 413
  start-page: 689
  year: 1990
  ident: BIB10
  publication-title: Rev. Plast. Modern.
  contributor:
    fullname: Román
– start-page: 231
  year: 1986
  ident: BIB14
  publication-title: Infrared and Raman Spectra of Inorganic and Coordination Compounds
  contributor:
    fullname: Nakamoto
– volume: 2
  start-page: 272
  year: 1994
  ident: BIB4
  publication-title: Trends Polym. Sci.
  contributor:
    fullname: Anstice
– volume: 27
  start-page: 1037
  year: 1994
  ident: BIB8
  publication-title: Otolaryngol. Clin.
  contributor:
    fullname: Friedman
– start-page: 704
  year: 1995
  ident: BIB5
  publication-title: The Biomedical Engineering Handbook
  contributor:
    fullname: Park
SSID ssj0006386
Score 1.6586782
Snippet The preparation of hard composites by the free radical polymerization at room temperature of a blend of β-tricalcium phosphate, poly(ethyl methacrylate),...
The preparation of hard composites by the free radical polymerization at room temperature of a blend of beta -tricalcium phosphate, poly(ethyl methacrylate),...
SourceID proquest
crossref
elsevier
SourceType Aggregation Database
Publisher
StartPage 887
SubjectTerms Biocomposites
Ceramic materials
Ceramic-drug complex
Controlled drug delivery
Drug products
Drug release
Fourier transform infrared spectroscopy
Free radical polymerization
Monomers
Polymer blends
Polymerization at room temperature
Polymethyl methacrylates
Synthesis (chemical)
Title Synthesis of ceramic-polymer-drug biocomposites at room temperature
URI https://dx.doi.org/10.1016/S0167-2738(97)00219-1
https://search.proquest.com/docview/21297651
https://search.proquest.com/docview/27375276
Volume 101
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3PS8MwFA5DEbyIP3H-mD140EO2pm2S9jiGYyruMge7hTRJpaDtaLvDLv7tJmnLVFDBa0jT8vX1fY--770HwHUQmHSu1N6PhhIGmgNh7EoXSuQRHspIKTsO6GlKJvPgYYEXHTBqa2GMrLLx_bVPt966WRk0aA6WaTqYGQG9KSyJqCGquoJd05-26f77Ruah7Yu0_b3N7k0VT32CXbyJ6K09BKKf-Ombp7b0M94He03c6AzrRzsAHZUdgh2r3xTlERjN1pkO5cq0dPLEEaowY-bhMn9dv6kCymL14sRpbvTjRqSlSodXjomZHdOaqumrfAzm47vn0QQ28xGg8CmqoI5eXMxNQzsSKY1swoUrYj9MQmJ-bSYcIy58pMxnlgQKIekiJbinRJQQIpF_ArayPFOnwOGYa2YnEfa5G_ixCGMUBTQQ0sOSujLpgn6LClvWbTDYJ30YoczAyGwyW8PIUBeELXbsy_tk2lX_delVizXTtm4SGDxT-apkmmZ19IR_20F9ij1Kzv5_-3Owa1vU2nrDC7BVFSt1qQOPKu5Zy-qB7eH942T6AceR0rg
link.rule.ids 315,783,787,4509,24128,27936,27937,45597,45691
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV07T8MwELYQCMGCeIryzMAAg9u4cexkRBVVeS5tpW6WYzsoEiRV0w5d-O34nEQ8JEBitRwn-nK5-5T77g6hC0ohnaut9-ORxtTGQJz42seadJmMdGyMGwf0-MQGY3o3CScrqNfUwoCssvb9lU933rpe6dRodqZZ1hmCgB4KS2IOgQoq2Nco8GNr1O23D52HNTDWNPiG7R9lPNURbvEy5lfuFEx-ClDfXLWLP_1ttFUTR--6erYdtGLyXbTuBJyq3EO94TK3XK7MSq9IPWVmMGceT4uX5auZYT1bPHtJVoCAHFRapvTk3APS7EFvqrqx8j4a929GvQGuByRgFXAyx5a--KGEjnYsNhbaVCpfJUGURgz-baYyJFIFxMB3llJDiPaJUbJrVJwypklwgFbzIjeHyJOhtKGdxWEgfRokKkpITDlVuhtq7uu0hdoNKmJa9cEQnwRijAuAUbhstoVRkBaKGuzElxcqrK_-69LzBmthjR0yGDI3xaIUNs5a-hT-toMHPOxydvT_25-jjcHo8UE83D7dH6NN16_WFR-eoNX5bGFOLQuZJ2fOyt4B3vfUUQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Synthesis+of+ceramic-polymer-drug+biocomposites+at+room+temperature&rft.jtitle=Solid+state+ionics&rft.au=Vallet-Regi%2C+M&rft.au=Gordo%2C+M&rft.au=Ragel%2C+C+V&rft.au=Cabanas%2C+M+V&rft.date=1997-11-01&rft.issn=0167-2738&rft.volume=101-103&rft.issue=pt+2&rft.spage=887&rft.epage=892&rft_id=info:doi/10.1016%2FS0167-2738%2897%2900219-1&rft.externalDBID=NO_FULL_TEXT&rft.externalDocID=316488
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0167-2738&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0167-2738&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0167-2738&client=summon