Synthesis of ceramic-polymer-drug biocomposites at room temperature

The preparation of hard composites by the free radical polymerization at room temperature of a blend of β-tricalcium phosphate, poly(ethyl methacrylate), methyl methacrylate monomer and fosfosal ® is described. After the immersion of the composites in a buffered solution, the controlled release of a...

Full description

Saved in:
Bibliographic Details
Published inSolid state ionics Vol. 101; no. pt 2; pp. 887 - 892
Main Authors Vallet-Regí, M., Gordo, M., Ragel, C.V., Cabañas, M.Y., Román, J.San
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.11.1997
Subjects
Biocomposites
Ceramic materials
Ceramic-drug complex
Controlled drug delivery
Drug products
Drug release
Fourier transform infrared spectroscopy
Free radical polymerization
Monomers
Polymer blends
Polymerization at room temperature
Polymethyl methacrylates
Synthesis (chemical)
Drug release
Polymerization at room temperature
Ceramic-drug complex
β-Tricalcium phosphate
Poly(ethyl methacrylate)
Methyl methacrylate
Biocomposites
Fosfosal
Online AccessGet full text

Cover

More Information
Summary:The preparation of hard composites by the free radical polymerization at room temperature of a blend of β-tricalcium phosphate, poly(ethyl methacrylate), methyl methacrylate monomer and fosfosal ® is described. After the immersion of the composites in a buffered solution, the controlled release of an analgesic drug, fosfosal, is observed. The ceramic component participates actively in the control of the release of the drug by means of the formation of a bridging complex with the fosfosal, as demonstrated by FTIR studies.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-2
ObjectType-Feature-1
content type line 23
SourceType-Conference Papers & Proceedings-1
ObjectType-Conference-3
ObjectType-Feature-2
ObjectType-Conference Paper-1
ObjectType-Article-3
ISSN:0167-2738
1872-7689
DOI:10.1016/S0167-2738(97)00219-1