Accelerated healing of a diabetic foot ulcer using autologous stromal vascular fraction suspended in platelet-rich plasma

We describe the case of a Type I diabetic patient with a refractory foot ulcer that remained unhealed for 2 years despite conventional therapy. Autologous adipose-derived stromal vascular fraction suspended in autologous platelet-rich plasma was applied to the wound, which completely healed within 1...

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Published inRegenerative medicine Vol. 13; no. 3; pp. 277 - 281
Main Authors Didangelos, Triantafyllos, Koliakos, George, Kouzi, Kokkona, Arsos, George, Kotzampassi, Katerina, Tziomalos, Konstantinos, Karamanos, Dimitrios, Hatzitolios, Apostolos I
Format Journal Article
LanguageEnglish
Published England Future Medicine Ltd 01.04.2018
Subjects
adipose-derived stomal vascular fraction
Antibiotics
autologous
Blood platelets
Diabetes
Diabetic retinopathy
diabetic ulcer
Flow cytometry
Foot diseases
Growth factors
Leg ulcers
mesenchymal stem cell
Patients
platelet-rich plasma
Skin
Stem cells
Systematic review
Tissue engineering
Wound healing
United States > US
mesenchymal stem cell
adipose-derived stomal vascular fraction
diabetic ulcer
diabetes
platelet-rich plasma
autologous
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Summary:We describe the case of a Type I diabetic patient with a refractory foot ulcer that remained unhealed for 2 years despite conventional therapy. Autologous adipose-derived stromal vascular fraction suspended in autologous platelet-rich plasma was applied to the wound, which completely healed within 1 month. The wound remained closed with no complications for a 2-year follow-up. Reporting of this and similar cases may lead to larger clinical trials that will prove the efficacy of this therapy that may offer accelerated healing and lessen the financial burden of more expensive therapeutic modalities.
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ISSN:1746-0751
1746-076X
DOI:10.2217/rme-2017-0069