Centers for disease control and prevention expert panel meetings on prevention and treatment of anthrax in adults

• Published in: Emerging infectious diseases Vol. 20; no. 2
• Main Authors: Hendricks, Katherine A, Wright, Mary E, Shadomy, Sean V, Bradley, John S, Morrow, Meredith G, Pavia, Andy T, Rubinstein, Ethan, Holty, Jon-Erik C, Messonnier, Nancy E, Smith, Theresa L, Pesik, Nicki, Treadwell, Tracee A, Bower, William A
• Format: Journal Article Conference Proceeding
• Language: English
• Published: United States Centers for Disease Control and Prevention 01.02.2014
• Subjects: Adult; anthrax; Anthrax - drug therapy; Anthrax - immunology; Anthrax - microbiology; Anthrax - prevention & control; Anthrax Vaccines - administration & dosage; Anti-Bacterial Agents - therapeutic use; Antibodies, Monoclonal - therapeutic use; antitoxin; Antitoxins - therapeutic use; Bacillus anthracis; Bacillus anthracis - drug effects; Bacillus anthracis - immunology; Bacillus anthracis - pathogenicity; bacteria; Bioterrorism; bioterrorism and preparedness; Centers for Disease Control and Prevention (U.S.); Clinical Competence; Critical Care; Disease Management; Humans; Immunoglobulins, Intravenous - therapeutic use; Online Report; Practice Guidelines as Topic; raxibacumab; United States; raxibacumab; Bacillus anthracis; treatment; bioterrorism and preparedness; Centers for Disease Control and Prevention; bacteria; antitoxin; adults; anthrax; expert panel meeting; prevention
• ISSN: 1080-6040; 1080-6059
• DOI: 10.3201/eid2002.130687

The Centers for Disease Control and Prevention convened panels of anthrax experts to review and update guidelines for anthrax postexposure prophylaxis and treatment. The panels included civilian and military anthrax experts and clinicians with experience treating anthrax patients. Specialties represented included internal medicine, pediatrics, obstetrics, infectious disease, emergency medicine, critical care, pulmonology, hematology, and nephrology. Panelists discussed recent patients with systemic anthrax; reviews of published, unpublished, and proprietary data regarding antimicrobial drugs and anthrax antitoxins; and critical care measures of potential benefit to patients with anthrax. This article updates antimicrobial postexposure prophylaxis and antimicrobial and antitoxin treatment options and describes potentially beneficial critical care measures for persons with anthrax, including clinical procedures for infected nonpregnant adults. Changes from previous guidelines include an expanded discussion of critical care and clinical procedures and additional antimicrobial choices, including preferred antimicrobial drug treatment for possible anthrax meningitis.