Continued versus discontinued oxytocin stimulation in the active phase of induced labour: Factors associated with unexpectedly high rates of conversion to open label oxytocin in the CONDISOX trial

• Published in: BJOG : an international journal of obstetrics and gynaecology Vol. 130; no. 6; pp. 636 - 642
• Main Authors: Steer, Philip J., Glavind, Julie, Uldbjerg, Niels, Bor, Pinar, Boie, Sidsel
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.05.2023
• Subjects: caesarean section; Cesarean Section; Clinical outcomes; Female; Humans; Induced labor; induction of labour; Labor, Induced; Obstetrics; Oxytocics; Oxytocin; oxytocin infusion; Pregnancy; Prospective Studies; Retrospective Studies; Denmark; Netherlands; induction of labour; oxytocin infusion; caesarean section
• ISSN: 1470-0328; 1471-0528
• DOI: 10.1111/1471-0528.17376

Objective To examine the factors associated with unexpectedly high rates of conversion to open label oxytocin in the CONDISOX trial of continuation versus discontinuation of oxytocin infusion during induced labour. Design Secondary retrospective analysis of data from a prospective randomised controlled trial. Setting Nine hospitals in Denmark and one in the Netherlands between 8 April 2016 and 30 June 2020. Population or sample 1200 women having labour induced. Methods Analysis of outcomes by actual management. Main outcome measures Mode of delivery and associated variables. Results Switching to open label oxytocin (42.4% overall) was associated with nulliparity, an unripe cervix, larger babies and higher rates of delivery by caesarean section. Conclusions In the CONDISOX trial, slow labour was associated with features suggesting a higher ‘resistance to progress’, often prompting the use of open‐label oxytocin infusion rather than study medication. Linked article: This article is commented on by G. J. Hofmeyr, pp. 643–644 in this issue. To view this mini commentary visit https://doi.org/10.1111/1471‐0528.17377.