Non‐invasive three‐dimensional power Doppler imaging for the assessment of acute cerebral blood flow alteration in a mouse model of subarachnoid haemorrhage

• Published in: Clinical and experimental pharmacology & physiology Vol. 46; no. 1; pp. 99 - 102
• Main Authors: Yamamoto, Shuzo, Mutoh, Tatsushi, Sasaki, Kazumasu, Mutoh, Tomoko, Tatewaki, Yasuko, Taki, Yasuyuki
• Format: Journal Article
• Language: English
• Published: Australia Wiley Subscription Services, Inc 01.01.2019
• Subjects: Aneurysms; Animals; Blood flow; Brain; Brain injury; Carotid Arteries - diagnostic imaging; Carotid Arteries - physiopathology; Carotid artery; Cerebral blood flow; Cerebrovascular Circulation; Disease Models, Animal; Doppler effect; Feasibility studies; Head injuries; Hemorrhage; Imaging, Three-Dimensional; Mice; Mice, Inbred C57BL; mouse model; Neuroimaging; subarachnoid haemorrhage; Subarachnoid hemorrhage; Subarachnoid Hemorrhage - diagnostic imaging; Subarachnoid Hemorrhage - physiopathology; Territory; Three dimensional flow; Ultrasonography, Doppler; Ultrasound; ultrasound imaging; ultrasound imaging; cerebral blood flow; subarachnoid haemorrhage; mouse model
• ISSN: 0305-1870; 1440-1681
• DOI: 10.1111/1440-1681.13035

Summary We aimed to evaluate the feasibility of a non‐invasive method of cerebral blood flow (CBF) measurement using high‐frequency power Doppler ultrasound imaging in a mouse model of subarachnoid haemorrhage (SAH). The 3‐dimensionally (3D) reconstructed blood flow signals (%vascularity) within the brain volume of the middle cerebral artery territory correlated well with reference parameters, baseline carotid artery blood flow (r2 = 0.52, P < 0.0001) and normalized CBF changes (r2 = 0.74 P < 0.0001). These data suggest that the 3D power Doppler analysis may have the potential for reflecting real‐time CBF changes during the acute phase of experimental SAH, which may be applicable to preclinical studies on early brain injury.