Comparison of analgesic and anti-inflammatory efficacy of selective and non-selective cyclooxygenase-2 inhibitors in dental implant surgery

• Published in: Journal of periodontology (1970) Vol. 78; no. 12; p. 2284
• Main Authors: Karabuda, Zihni Cuneyt, Bolukbasi, Nilufer, Aral, Ali, Basegmez-Zeren, Cansu, Ozdemir, Tayfun
• Format: Journal Article
• Language: English
• Published: United States 01.12.2007
• Subjects: Analgesics - administration & dosage; Cyclooxygenase 2 Inhibitors - administration & dosage; Dental Implantation, Endosseous - adverse effects; Double-Blind Method; Female; Humans; Male; Middle Aged; Pain Measurement; Pain, Postoperative - etiology; Pain, Postoperative - prevention & control; Piroxicam - administration & dosage; Piroxicam - analogs & derivatives; Premedication; Prospective Studies; Thiazines - administration & dosage; Thiazoles - administration & dosage
• ISSN: 0022-3492
• DOI: 10.1902/jop.2007.070192

The analgesic and anti-inflammatory efficacy of tenoxicam and meloxicam were evaluated in this double-masked, randomized, prospective study by analyzing pain scores and the need for rescue-analgesic agents following dental implant surgery. One hundred patients, in whom 241 dental implants were placed, were divided into two groups. For 4 days beginning the day before surgery, the first group received meloxicam, 15 mg daily, and the second group received tenoxicam, 20 mg daily, followed by 1 hour preoperatively and for 2 days thereafter. Pain intensity was rated by the subjects based on a visual analog scale on the operation day and on the following 6 days. The patients were recommended to use a rescue analgesic if the pain score was > or =4. Postoperative complications, such as edema, hematoma, infection, severe pain, paresthesia, or gastrointestinal complaints, were also noted. Statistical analysis revealed that 54% of patients in the tenoxicam group and 66% of patients in the meloxicam group used rescue analgesics on day 1. However, the difference between the groups was not significant (chi(2) = 1.05; P = 0.30). The relationship between the reduction of consumption and time was not significant in either group (Z = 0.84; P = 0.40). The relationship between the use of rescue analgesics and the number of implants placed was not significant. Among patients who reported postoperative complications, there was not a statistically significant difference between the groups (chi(2) = 0.04; P = 0.84). Meloxicam and tenoxicam exhibited a similar analgesic and anti-inflammatory efficacy in the present investigation.