Incidence of sleep disturbances in patients with familial Mediterranean fever and the relation of sleep quality with disease activity

• Published in: International journal of rheumatic diseases Vol. 21; no. 10; pp. 1849 - 1856
• Main Authors: Kucuksahin, Orhan, Omma, Ahmet, Ozdemirel, Ali Erhan, Tecer, Duygu, Ulutas, Sümeyye, Maras, Yüksel, Balkarlı, Ayşe, Erten, Şükran
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.10.2018
• Subjects: Adult; Affect; Amyloid; Anxiety; Anxiety - epidemiology; Anxiety - psychology; Case-Control Studies; Cross-Sectional Studies; Depression - epidemiology; Depression - psychology; disease activity; Erythrocyte sedimentation rate; Familial Mediterranean fever; Familial Mediterranean Fever - diagnosis; Familial Mediterranean Fever - epidemiology; Familial Mediterranean Fever - physiopathology; Familial Mediterranean Fever - psychology; Fatigue; Fatigue - epidemiology; Fatigue - physiopathology; Fatigue - psychology; Female; Health Status; Humans; Incidence; Inflammation; Male; Mental depression; Mental Health; mood disorders; Quality; Quality of Life; Regression analysis; Severity of Illness Index; Sleep; Sleep deprivation; sleep disturbances; Sleep Wake Disorders - diagnosis; Sleep Wake Disorders - epidemiology; Sleep Wake Disorders - physiopathology; Sleep Wake Disorders - psychology; Turkey - epidemiology; Young Adult; Turkey; disease activity; sleep disturbances; fatigue; familial Mediterranean fever; mood disorders
• ISSN: 1756-1841; 1756-185X
• DOI: 10.1111/1756-185X.13104

Aim To evaluate the sleep quality and the relation of sleep quality with depression, anxiety, fatigue and disease activity in adult patients with familial Mediterranean fever (FMF). Method One hundred and seventy‐four FMF patients and 84 age‐sex matched healthy individuals were included in this study. The Pittsburgh Sleep Quality Index (PSQI), Multidimensional Assessment of Fatigue (MAF) and the Hospital Anxiety and Depression Index (HADS) were used to assess sleep quality, fatigue, depression and anxiety, respectively. Result FMF patients had significantly higher depression, anxiety, fatigue and PSQI scores than healthy controls. As the severity of the disease increased, scores of total PSQI and its domains increased. Patients with total PSQI score higher than 5 had statistically significantly higher erythrocyte sedimentation rates (ESR), serum C‐reactive protein and serum amyloid levels during attacks, more attack numbers in last 3 months and worse fatigue, depression scores. Total PSQI score was positively correlated with inflammatory markers during attacks, attack numbers in the last 3 months and fatigue score. Logistic regression models identified disease duration, ESR during attacks, fatigue, attack numbers in the last 3 months as predictors of poor sleep quality. Conclusion Poor sleep quality is common in adult FMF patients. Anxiety, depression and fatigue are more frequent in FMF patients than healthy individuals. Poor sleep quality is associated with inflammatory marker levels during attacks, fatigue and attack numbers in the last 3 months.