Genetic, developmental, and physical factors associated with attention deficit hyperactivity disorder in patients with velocardiofacial syndrome
Velocardiofacial syndrome (VCFS) is a relatively common developmental neuropsychiatric syndrome caused by a 22q11 microdeletion. There is an extensive variability in the phenotypic expression of this disease. The most common psychiatric disorder in VCFS is attention‐deficit/hyperactivity disorder (A...
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Published in | American journal of medical genetics. Part B, Neuropsychiatric genetics Vol. 126B; no. 1; pp. 116 - 121 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.04.2004
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Subjects | |
Online Access | Get full text |
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Summary: | Velocardiofacial syndrome (VCFS) is a relatively common developmental neuropsychiatric syndrome caused by a 22q11 microdeletion. There is an extensive variability in the phenotypic expression of this disease. The most common psychiatric disorder in VCFS is attention‐deficit/hyperactivity disorder (ADHD), affecting 35–55% of patients. This study investigated the association of familial, developmental, and physical factors with the occurrence of ADHD in 51 patients with nonfamilial VCFS. Twenty‐one patients (41.2%) were diagnosed with ADHD. There was a significantly greater prevalence of ADHD in the first‐degree relatives of the patients with ADHD than in those without (OR = 5.9, 95% CI = 1.6–22.1, P = 0.006). No differences were noted between the ADHD and non‐ADHD groups in mean Obstetric Complication Scale Score, gestational age, birth weight, age at first words, walking, and achieving bowel control. The two groups also had similar IQ scores (total, verbal, and performance) and had a similar average degree of severity of facial dysmorphism and cardiac and cleft anomalies. These findings indicate that ADHD in VCFS has a genetic contribution and the patients' VCFS‐related developmental factors and physical illnesses play a lesser role. © 2003 Wiley‐Liss, Inc. |
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Bibliography: | istex:808FDEF4916E9BC7CA2673BE67096AF9136FCE35 ArticleID:AJMG20144 National Institute for Psychobiology in Israel, Founded by the Charles E. Smith Family - No. 132003 ark:/67375/WNG-8VTTRJHC-K ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1552-4841 1552-485X |
DOI: | 10.1002/ajmg.b.20144 |