Cytotoxic benzopyranone and xanthone derivatives from a coral symbiotic fungus Cladosporium halotolerans GXIMD 02502

Coral-derived microorganisms have been historically proven to be prolific sources of bioactive secondary metabolites. Twelve benzopyranone and/or xanthone derivatives, including a new benzopyranone with an uncommon carboxyl group at C-8, coniochaetone K (1), were obtained from the Beibu Gulf-derived...

Full description

Saved in:
Bibliographic Details
Published inNatural product research Vol. 35; no. 24; pp. 5596 - 5603
Main Authors Wang, Chao-Nan, Lu, Hu-Mu, Gao, Cheng-Hai, Guo, Lang, Zhan, Zhen-Yu, Wang, Jun-Jian, Liu, Yong-Hong, Xiang, Song-Tao, Wang, Jian, Luo, Xiao-Wei
Format Journal Article
LanguageEnglish
Published Taylor & Francis 17.12.2021
Subjects
Benzopyranones
Cladosporium halotolerans
coral-derived fungi
cytotoxicity
xanthones
Online AccessGet full text

Cover

More Information
Summary:Coral-derived microorganisms have been historically proven to be prolific sources of bioactive secondary metabolites. Twelve benzopyranone and/or xanthone derivatives, including a new benzopyranone with an uncommon carboxyl group at C-8, coniochaetone K (1), were obtained from the Beibu Gulf-derived coral symbiotic fungus Cladosporium halotolerans GXIMD 02502. Their structures were determined by extensive spectroscopic data interpretation and comparison with literature values. The absolute configuration of 1 was accomplished by comparison of specific optical rotation as well as quantum chemical ECD calculations. The in vitro cytotoxicity of compounds 1-12 against two human prostatic cancer cell lines, C4-2B and 22RV1, were evaluated. And compounds 1, 3, 6-8, and 10-11 demonstrated significant cytotoxicity with inhibitions ranging from 55.8% to 82.1% at the concentration of 10 μM.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2020.1799363