Stereochemistry of a Curare Alkaloid: O,O′,N-trimethyl-d-tubocurarine

The three-dimensional structure of O,O′,N-trimethyl-d-tubocurarine, a neuromuscular blocking agent, has been determined by x-ray crystallography. This may help to provide insight into its pharmacologic action.

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Bibliographic Details
Published inProceedings of the National Academy of Sciences - PNAS Vol. 69; no. 8; pp. 2212 - 2215
Main Authors Sobell, Henry M., Sakore, T. D., Tavale, S. S., Canepa, F. G., Pauling, Peter, Petcher, Trevor J.
Format Journal Article
LanguageEnglish
Published United States National Academy of Sciences of the United States of America 01.08.1972
National Acad Sciences
Subjects
Anions
Atoms
Biological Sciences: Biochemistry
Cholinergic agents
Cholinergic receptors
Crystal structure
Crystallography
Drug interactions
Iodides
Least squares
Methods
Models, Structural
Molecules
Nitrogen
Stereochemistry
Temperature
Tubocurarine
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Summary:The three-dimensional structure of O,O′,N-trimethyl-d-tubocurarine, a neuromuscular blocking agent, has been determined by x-ray crystallography. This may help to provide insight into its pharmacologic action.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Department of Physics, North of London Polytechnic, London N.7.
Department of Chemistry, Indian Institute of Technology, Bombay, India.
National Chemical Laboratories, Poona, India.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.69.8.2212