Treatment of progressive systemic sclerosis (scleroderma, PSS) with a new drug influencing connective tissue

Cyclofenil is a new diphenyl ethylene derivative related to stilboestrol without oestrogenicity but with marked effects on connective tissue metabolism. The drug has been tested, in a daily dose of 200mg X3, in six patients with progressive systemic sclerosis (PSS) to analyze the expected beneficial...

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Bibliographic Details
Published inActa medica Scandinavica Vol. 201; no. 3; p. 203
Main Authors Herbai, G, Blom, B, Boström, H
Format Journal Article
LanguageEnglish
Published Sweden 01.01.1977
Subjects
Administration, Oral
Adult
Aged
Chemical Phenomena
Chemistry
Cresols - therapeutic use
Cyclofenil - administration & dosage
Cyclofenil - adverse effects
Cyclofenil - therapeutic use
Drug Evaluation
Female
Humans
Male
Middle Aged
Scleroderma, Systemic - drug therapy
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Summary:Cyclofenil is a new diphenyl ethylene derivative related to stilboestrol without oestrogenicity but with marked effects on connective tissue metabolism. The drug has been tested, in a daily dose of 200mg X3, in six patients with progressive systemic sclerosis (PSS) to analyze the expected beneficial effects on the PSS symptoms. The typical skin hardness, joint and muscle rigidity, and reduced breathing capacity were improved to varying dgrees. The only side-effect was a slight transient liver enzyme elevation in 1 out of 6 patients. A slight increase was found in urinary calcium and hydroxyproline excretion. In several cases serum calcium, cholesterol, triglyceride and in some cases the serum uric acid levels were decreased. The ANF titres diminished to varying degrees in 4 out of 6 patients. These results indicate that further detailed clinical and laboratory studies on the therapeutic potential of cyclofenil in PSS and other diseases affecting connective tissue seen to be justified.
ISSN:0001-6101
DOI:10.1111/j.0954-6820.1977.tb15682.x