In vivo biological evaluation of sodium salt of ethyl (E)‐2‐cyano‐3‐(7‐hydroxy‐4‐methyl‐2‐oxoquinoline‐1(2H)‐yl)‐3‐(4‐hydroxyphenyl) acrylate as anticancer agent

• Published in: Clinical and experimental pharmacology & physiology Vol. 49; no. 1; pp. 145 - 174
• Main Authors: Mohammed, Faten Z., Abd El‐Aziz, Rahma M., El‐Deen, Ibrahim M., Abd‐Rahman, Marwa S., AlGhannam, Sheikha M.
• Format: Journal Article
• Language: English
• Published: Australia Wiley Subscription Services, Inc 01.01.2022
• Subjects: Animals; anticancer; Anticancer properties; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Antioxidants; Antioxidants - pharmacology; Antioxidants - therapeutic use; Antitumor agents; Apoptosis; Ascites; Biomedical materials; Carcinoma, Ehrlich Tumor - drug therapy; Caspase-3; Cell size; docking study; Dose-Response Relationship, Drug; Drug development; EAC cells; Evaluation; Female; Kidneys; Lethal Dose 50; Mice; Molecular Docking Simulation; Molecular Structure; Osteopontin; Quinoline; Quinolones - pharmacology; Quinolones - therapeutic use; Salt; Salts; Sodium; Sodium salts; apoptosis; quinoline; docking study; EAC cells; antioxidants; anticancer

Nowadays, quinoline scaffold is among the most vital construction compounds for the development of new drugs. The purpose of this research is to evaluate the anti‐cancer activity of sodium salt of ethyl (E)‐2‐cyano‐3‐(7‐hydroxy‐4‐methyl‐2‐oxoquinoline‐1(2H)‐yl)‐3‐(4‐hydroxyphenyl) acrylate against E...