In vivo biological evaluation of sodium salt of ethyl (E)‐2‐cyano‐3‐(7‐hydroxy‐4‐methyl‐2‐oxoquinoline‐1(2H)‐yl)‐3‐(4‐hydroxyphenyl) acrylate as anticancer agent

• Published in: Clinical and experimental pharmacology & physiology Vol. 49; no. 1; pp. 145 - 174
• Main Authors: Mohammed, Faten Z., Abd El‐Aziz, Rahma M., El‐Deen, Ibrahim M., Abd‐Rahman, Marwa S., AlGhannam, Sheikha M.
• Format: Journal Article
• Language: English
• Published: Australia Wiley Subscription Services, Inc 01.01.2022
• Subjects: Animals; anticancer; Anticancer properties; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Antioxidants; Antioxidants - pharmacology; Antioxidants - therapeutic use; Antitumor agents; Apoptosis; Ascites; Biomedical materials; Carcinoma, Ehrlich Tumor - drug therapy; Caspase-3; Cell size; docking study; Dose-Response Relationship, Drug; Drug development; EAC cells; Evaluation; Female; Kidneys; Lethal Dose 50; Mice; Molecular Docking Simulation; Molecular Structure; Osteopontin; Quinoline; Quinolones - pharmacology; Quinolones - therapeutic use; Salt; Salts; Sodium; Sodium salts; apoptosis; quinoline; docking study; EAC cells; antioxidants; anticancer
• ISSN: 0305-1870; 1440-1681
• DOI: 10.1111/1440-1681.13592

Nowadays, quinoline scaffold is among the most vital construction compounds for the development of new drugs. The purpose of this research is to evaluate the anti‐cancer activity of sodium salt of ethyl (E)‐2‐cyano‐3‐(7‐hydroxy‐4‐methyl‐2‐oxoquinoline‐1(2H)‐yl)‐3‐(4‐hydroxyphenyl) acrylate against Ehrlich ascites carcinoma (EAC) cells residing in female mice's peritoneal cavity. The docking study exhibited a favourable interaction between the compound and the receptors 1MOY and 3KJF of osteopontin and caspase 3, respectively. The compound's sodium salt showed potential antioxidant and anti‐cancer effects against Ehrlich ascites carcinoma (EAC) cells in vivo. Herein, the results elucidated that treatment with the compound's sodium salt exerted significant chemopreventive and chemotherapeutic effects, which reduced both EAC cell volume and count. Our results revealed that treatment with the sodium salt of the compound demonstrated a remarkable in vivo apoptotic effect through elevation of the expression of caspase 3 and reduction of osteopontin levels. Histopathological examination confirmed that the compound's sodium salt improved liver and kidney tissues without any apparent adverse effects.