Oral and rectal colonization of methicillin-resistant Staphylococcus aureus in long-term care facility residents and their association with clinical status

Staphylococcus aureus is a commensal bacterium in humans, but it sometimes causes opportunistic infectious diseases such as suppurative skin disease, pneumonia, and enteritis. Therefore, it is important to determine the prevalence of S. aureus and methicillin-resistant S. aureus (MRSA) in individual...

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Published inMicrobiology and immunology
Main Authors Kusaka, Satoru, Haruta, Azusa, Kawada-Matsuo, Miki, Nguyen-Tra Le, Mi, Yoshikawa, Mineka, Kajihara, Toshiki, Yahara, Koji, Hisatsune, Junzo, Nomura, Ryota, Tsuga, Kazuhiro, Ohge, Hiroki, Sugai, Motoyuki, Komatsuzawa, Hitoshi
Format Journal Article
LanguageEnglish
Published Australia 01.03.2024
Subjects
oral cavity
long-term care facility
antibiotic resistance
Staphylococcus aureus
MRSA
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Summary:Staphylococcus aureus is a commensal bacterium in humans, but it sometimes causes opportunistic infectious diseases such as suppurative skin disease, pneumonia, and enteritis. Therefore, it is important to determine the prevalence of S. aureus and methicillin-resistant S. aureus (MRSA) in individuals, especially older adults. In this study, we investigated the prevalence of S. aureus and MRSA in the oral cavity and feces of residents in long-term care facilities (LTCFs). S. aureus was isolated from the oral cavity of 61/178 (34.3%) participants, including 28 MRSA-positive participants (15.7%), and from the feces of 35/127 (27.6%) participants, including 16 MRSA-positive participants (12.6%). S. aureus and MRSA were isolated from both sites in 19/127 individuals (15.0%) and 10/127 individuals (7.9%), respectively. Among 19 participants with S. aureus isolation from both sites, 17 participants showed the same sequence type (ST) type. Then, we analyzed the correlation of S. aureus and MRSA in the oral cavity and rectum with the participant's condition. S. aureus and MRSA positivity in the oral cavity was significantly related to tube feeding, while there was no correlation of rectal S. aureus/MRSA with any factors. Our findings regarding the oral inhabitation of MRSA and its risk factors indicate the importance of considering countermeasures against MRSA infection in LTCFs.
ISSN:1348-0421
DOI:10.1111/1348-0421.13111