Generalized hereditary gingival fibromatosis in a child: clinical, histopathological and therapeutic aspects

Hereditary gingival fibromatosis (HGF) is a rare genetic condition characterized by slow and progressive gingival enlargement. The gingival overgrowth often delays teeth eruption and may cause serious functional and aesthetic problems. We reported a case of a 10-year-old female child presenting a ge...

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Bibliographic Details
Published inAutopsy & case reports Vol. 10; no. 1; p. e2020140
Main Authors Cunha, John Lennon Silva, Ramos, Maria Alice Carvalho da Cruz, Regis, Débora Menezes, Sanchéz-Romero, Celeste, de Andrade, Maria Eliane, Bezerra, Bruno Torres, de Albuquerque-Júnior, Ricardo Luiz Cavalcanti
Format Journal Article
LanguageEnglish
Published Brazil São Paulo, SP: Universidade de São Paulo, Hospital Universitário 2020
Hospital Universitário da Universidade de São Paulo
University of São Paulo
Subjects
ANATOMY & MORPHOLOGY
Clinical Case Report
Dentition
Fibromatosis
Gingiva
Gingival
Gingivectomy
PATHOLOGY
Permanent
Gingivectomy
Gingiva
Dentition, Permanent
Fibromatosis, Gingival
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Summary:Hereditary gingival fibromatosis (HGF) is a rare genetic condition characterized by slow and progressive gingival enlargement. The gingival overgrowth often delays teeth eruption and may cause serious functional and aesthetic problems. We reported a case of a 10-year-old female child presenting a generalized gingival enlargement covering almost all the maxillary and mandibular teeth and resulted in problems for swallowing, speaking, and poor aesthetics. An incisional biopsy was performed and revealed a hypocellular and hypovascular dense collagenous tissue covered by squamous epithelium exhibiting acanthosis and elongated rete ridges. The diagnosis was HGF. The treatment instituted was an association of gingivectomy with a rigorous program of oral hygiene and follow-up. Herein, we describe a rare non-syndromic case of generalized HGF, including clinical and microscopical features, as well as highlighting the importance of correct diagnosis of this genetic condition.
Bibliography:Author contributions:
Bezerra BT performed the surgical procedure. Albuquerque-Júnior RLC and de Sánchez-Romero C performed the microscopy analysis. Andrade ME performed the critical review of the manuscript. Cunha JLS, Ramos MACC, and Regis DM reviewed the literature and wrote the manuscript. All authors approved and proofread the final document.
Conflict of interest: None
ISSN:2236-1960
2236-1960
DOI:10.4322/acr.2020.140