Chronic tissue inflammation and metabolic disease

• Published in: Genes & development Vol. 35; no. 5-6; pp. 307 - 328
• Main Authors: Lee, Yun Sok, Olefsky, Jerrold
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.03.2021
• Subjects: Review; metaflammation; β-cell dysfunction; immunometabolism; inflammation; glucose intolerance; macrophage; insulin resistance

Obesity is the most common cause of insulin resistance, and the current obesity epidemic is driving a parallel rise in the incidence of T2DM. It is now widely recognized that chronic, subacute tissue inflammation is a major etiologic component of the pathogenesis of insulin resistance and metabolic...