DIFFERENTIAL ELIMINATION OF SYNTHETIC BUTYRIC TRIGLYCERIDES IN-VIVO - A PHARMACOKINETIC STUDY

New butyrate derivatives were synthesized to investigate the residence time of potent butyric acid in vivo. These derivatives were triglycerides in which one, two, or three butyric acid molecules were bound to glycerol or to mono- and dipalmitic esters of glycerol. Pharmacokinetic studies showed tha...

Full description

Saved in:
Bibliographic Details
Published inJournal of pharmaceutical sciences Vol. 82; no. 10; pp. 1046 - 1048
Main Authors PLANCHON, P, POUILLART, P, RONCO, G, VILLA, P, PIERI, F
Format Journal Article
LanguageEnglish
Published WASHINGTON AMER PHARMACEUTICAL ASSN 01.10.1993
Subjects
Animals
Butyrates - metabolism
Butyrates - pharmacokinetics
Butyrates - toxicity
Butyric Acid
Chemistry
Chemistry, Medicinal
Chemistry, Multidisciplinary
Chromatography, Gas
Drug Stability
Esterification
Life Sciences & Biomedicine
Mice
Pharmacology & Pharmacy
Physical Sciences
Rabbits
Science & Technology
Triglycerides - metabolism
CELLS
SODIUM-BUTYRATE
FATTY-ACID
Online AccessGet more information

Cover

More Information
Summary:New butyrate derivatives were synthesized to investigate the residence time of potent butyric acid in vivo. These derivatives were triglycerides in which one, two, or three butyric acid molecules were bound to glycerol or to mono- and dipalmitic esters of glycerol. Pharmacokinetic studies showed that a constant plasma level of each compound was maintained for a long time; all molecules had identical volumes of distribution, but differed about their mean residence time. Triesters in which palmitic acid was present displayed no toxicity and seemed to be even more stable in the organism; this may be due to their adsorption on the tissue. Other triglycerides constituted by butyric acid and various long fatty acids may be synthesized and useful in long-term clinical treatment.
ISSN:0022-3549
DOI:10.1002/jps.2600821016