Fungal benzene carbaldehydes: occurrence, structural diversity, activities and biosynthesis

Covering: up to April 2020 Fungal benzene carbaldehydes with salicylaldehydes as predominant representatives carry usually hydroxyl groups, prenyl moieties and alkyl side chains. They are found in both basidiomycetes and ascomycetes as key intermediates or end products of various biosynthetic pathwa...

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Published inNatural product reports Vol. 38; no. 1; pp. 24 - 263
Main Authors Ran, Huomiao, Li, Shu-Ming
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 01.01.2021
Subjects
Aldehydes
Benzene
Benzoic acid
Benzyl alcohol
Biosynthesis
Fungi
Hydrocarbons
Hydroxyl groups
Intermediates
Oxidation
polyketide synthases
polyketides
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Summary:Covering: up to April 2020 Fungal benzene carbaldehydes with salicylaldehydes as predominant representatives carry usually hydroxyl groups, prenyl moieties and alkyl side chains. They are found in both basidiomycetes and ascomycetes as key intermediates or end products of various biosynthetic pathways and exhibit diverse biological and pharmacological activities. The skeletons of the benzene carbaldehydes are usually derived from polyketide pathways catalysed by iterative fungal polyketide synthases. The aldehyde groups are formed by direct PKS releasing, reduction of benzoic acids or oxidation of benzyl alcohols. This review summarizes 185 fungal benzene carbaldehydes and discusses their structural features, distribution, biological activities and biosynthesis.
Bibliography:Huomiao Ran received her Bachelor's degree in 2013 from Hainan University and obtained her Master's degree in 2016 from Nanjing Agricultural University. She is currently a PhD student at the Philipps-Universität Marburg. Her research focuses on pathway elucidation of fungal secondary metabolites and characterisation of the involved enzymes under the supervision of Prof. Shu-Ming Li.
Shu-Ming Li is full professor of Pharmaceutical Biology and Biotechnology at the Philipps-University in Marburg, Germany. He studied pharmacy and received his Bachelor's and Master's degrees from Beijing University, China. Shu-Ming Li was awarded in 1992 his PhD in natural product chemistry by the Rheinische Friedrich-Wilhelms-University in Bonn, Germany. He has served as an associate professor of Pharmaceutical Biology at the Heinrich-Heine-University in Düsseldorf. Li's group is interested in the biosynthesis of secondary metabolites in bacteria and fungi.
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ISSN:0265-0568
1460-4752
1460-4752
DOI:10.1039/d0np00026d