Crowdsourcing for mining new fungal sources for addressing the need for novel antibiotics against multidrug resistant pathogens

There are a limited number of new antibiotics to manage the health crisis caused by the evolution and spread of antimicrobial resistant (AMR) bacteria including multidrug resistant (MDR), extensively drug-resistant (XDR) and pan-drug-resistant (PDR) ones. Bioprospecting fungi of less studied and ext...

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Bibliographic Details
Published inJournal of antibiotics Vol. 77; no. 6; pp. 335 - 337
Main Author Suryanarayanan, T. S.
Format Journal Article
LanguageEnglish
Published Tokyo Springer Japan 01.06.2024
Nature Publishing Group
Subjects
631/154
631/1647/2234
Antibiotics
Bacteriology
Biomedical and Life Sciences
Bioorganic Chemistry
Bioprospecting
Crowdsourcing
Drug resistance
Extreme environments
Life Sciences
Medicinal Chemistry
Microbiology
Multidrug resistance
Organic Chemistry
Pathogens
Perspective
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Summary:There are a limited number of new antibiotics to manage the health crisis caused by the evolution and spread of antimicrobial resistant (AMR) bacteria including multidrug resistant (MDR), extensively drug-resistant (XDR) and pan-drug-resistant (PDR) ones. Bioprospecting fungi of less studied and extreme environments using new and less used older approaches could reveal novel antibiotics to manage MDR pathogens. Furthermore, I posit a crowdsourcing model which could substantially increase the chances of discovering novel antibiotics as well as new chemotypes for other therapeutic areas and considerably reduce the cost and time of this exercise.
Bibliography:SourceType-Scholarly Journals-1
ObjectType-Commentary-2
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ObjectType-Review-1
ObjectType-Editorial-3
ISSN:0021-8820
1881-1469
1881-1469
DOI:10.1038/s41429-024-00723-5