Axon guidance: GTPases help axons reach their targets

• Published in: Current biology Vol. 8; no. 3; pp. R80 - R82
• Main Authors: Gallo, Gianluca, Letourneau, Paul C
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 29.01.1998
• Subjects: Animals; Axons - physiology; Caenorhabditis elegans - embryology; Caenorhabditis elegans - genetics; cdc42 GTP-Binding Protein; Cell Cycle Proteins - physiology; Dendrites - physiology; Enzyme Activation; GTP Phosphohydrolases - physiology; GTP-Binding Proteins - physiology; Multigene Family; Nervous System - growth & development; Neuroblastoma - pathology; rac GTP-Binding Proteins; rho GTP-Binding Proteins; Signal Transduction - physiology; Tumor Cells, Cultured

During development and regeneration of the nervous system, axons must correctly navigate to their specific targets through a complex molecular environment. Recent work has shed light on how GTPases of the Ras family are involved in transducing extracellular signals into responses that lead to direct...