Study of the effect of melafen at low doses on animal malignant neoplasms in vivo and in vitro

The goal of this work was to study the effect of melafen at low concentrations on apoptosis induction and inhibition factors in cells of the EAC cells in vitro and the development of transplantable solid tumors (Lewis carcinoma in mice) in vivo.

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Bibliographic Details
Published inDoklady. Biochemistry and biophysics Vol. 431; no. 1; pp. 76 - 78
Main Authors Alekseeva, O. M., Erokhin, V. N., Krementsova, A. V., Mil, E. M., Binyukov, V. I., Fattakhov, S. G., Kim, Yu. A., Semenov, V. A., Goloshchapov, A. N., Burlakova, E. B., Konovalov, A. I.
Format Journal Article
LanguageEnglish
Published Dordrecht SP MAIK Nauka/Interperiodica 01.04.2010
Springer Nature B.V
Subjects
Animals
Apoptosis
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Biophysics and Molecular Biology
Calcium - metabolism
Carcinoma, Ehrlich Tumor
Cell Line, Tumor
Cells
In Vitro Techniques
Kinetics
Life Sciences
Mice
Neoplasm Transplantation
Neoplasms - drug therapy
Phosphinic Acids - pharmacology
Proto-Oncogene Proteins c-bcl-2 - metabolism
Receptors, Purinergic P2 - metabolism
Rodents
Signal Transduction
Time Factors
Triazines - pharmacology
Tumor Suppressor Protein p53 - metabolism
Tumors
DOKLADY Biochemistry
Oxymethyl
Tumor Volume
Melamine
Phosphinic Acid
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Summary:The goal of this work was to study the effect of melafen at low concentrations on apoptosis induction and inhibition factors in cells of the EAC cells in vitro and the development of transplantable solid tumors (Lewis carcinoma in mice) in vivo.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1607-6729
1608-3091
DOI:10.1134/S1607672910020067