Synthesis of novel triazol compounds containing isatin as potential antibacterial and antifungal agents by microwave and conventional methods

Microwave irradiation has been used to accelerate the conversion of isatin (1a) and 5-nitroisatin (1b) into their Schiff bases 3-[5'-aryl(alkyl)-2',4'-dihydro-1',2',4'-triazol-3'-on-4'-yl]iminoisatin (3a-g) and 3-[5'-aryl(alkyl)-2',4'-dihydro-1&...

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Bibliographic Details
Published inJournal of chemical research Vol. 35; no. 5; pp. 268 - 271
Main Authors Ozil, Musa, Mentese, Emre, Yilmaz, Fatih, Islamoglu, Fatih, Kahveci, Bahittin
Format Journal Article
LanguageEnglish
Published ST ALBANS Science Reviews 2000 Ltd 01.05.2011
Sage Publications Ltd
Subjects
Antifungal agents
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
ASSISTED SYNTHESIS
Schiff bases
ORGANIC-SYNTHESIS
antifugal
triazoles
5-nitroisatin
microwave irradiation
antibacterial
THIOSEMICARBAZONE DERIVATIVES
isatin
DISCOVERY
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Summary:Microwave irradiation has been used to accelerate the conversion of isatin (1a) and 5-nitroisatin (1b) into their Schiff bases 3-[5'-aryl(alkyl)-2',4'-dihydro-1',2',4'-triazol-3'-on-4'-yl]iminoisatin (3a-g) and 3-[5'-aryl(alkyl)-2',4'-dihydro-1',2',4'-triazol-3'-on-4'-yl]imino-5-nitroisatin (4a-g), respectively. Reaction was achieved by microwave-induced technique, which reduced the reaction time drastically and improved the yield when compared to conventional heating. The newly synthesised bases showed moderate antimicrobial activity against the standard bacterial and fungal organisms tested
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1747-5198
2047-6507
DOI:10.3184/174751911X13043524455143