Study on the Relationship between Chinese Medicine Constitutive Susceptibility and Diversity of Syndrome in Diabetic Nephropathy

• Published in: Chinese journal of integrative medicine Vol. 19; no. 9; pp. 656 - 662
• Main Author: 牟新 周迪夷 刘文洪 周旦阳 刘颖慧 胡永宾 寿成珉 陈家炜 赵进喜 马国玲
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2013
• Subjects: Aged; Body Constitution; Cluster Analysis; Diabetic Nephropathies - therapy; Female; Humans; Male; Medicine; Medicine & Public Health; Medicine, Chinese Traditional; Original Article; Syndrome; 中国医药; 典型相关分析; 多样性; 易感性; 流行病学调查; 糖尿病肾病; 综合症; 辨证分型; Chinese medicine constitution; diabetic nephropathy; syndromatologic study
• ISSN: 1672-0415; 1993-0402; 1993-0402
• DOI: 10.1007/s11655-013-1411-0

Objective： To explore the relationship between Chinese medicine （CM） constitutive susceptibility and syndrome diversity in diabetic nephropathy （DN）. Methods： Epidemiologic investigation on constitution adopting the ＂Constitution in Chinese Medicine Questionnaire＂ （CCMQ）, and survey on syndrome type by CM syndrome scale （preliminary） were carried out in 180 DN patients. Cluster analysis on symptom items was used to determine the syndrome type, and canonical correlation analysis was used to analyze the relationship between patients＇ constitution and syndrome. Results： Baseline levels in all enrolled patients were not different statistically. Cluster analysis showed 8 syndromes existed in DN patients, namely： Ⅰ, qi-yin deficiency with qi- stagnancy type; Ⅱ, yin-yang deficiency with heat-water-blood stasis type; Ⅲ, qi-yin deficiency with dampness- heat type; Ⅳ, yin-yang deficiency with blood-stasis and heat type; Ⅴ, qi-yin deficiency with stagnant heat type; Ⅵ, yin-yang deficiency with inner dampness-heat stagnancy type; Ⅶ, yin deficiency with heat stagnancy type; and Ⅷ, Kidney （Shen）-Spleen （Pi） deficiency with stagnant heat type. Correlation analysis on the 8 syndromes and the 9 constitutions showed statistical significant correlations between syndrome Ⅲ and dampness-heat constitution （P=0.0001）; syndrome Ⅳ and blood-stasis constitution （P=0.0001）; and syndrome Ⅶ and yin-deficiency constitution （P=0.0180）. Conclusion： Certain relationship revealed between CM constitutions and syndrome types; constitution decides the disease genesis, its syndrome type and prognosis, as well as the change of syndromes.