Recent advances in radical transformations of internal alkynes
Over the past years, impressive progress has been made on the development of the chemoselective and direct formation of carbon-carbon and carbon-heteroatom bonds involving internal alkynes under catalytic oxidative systems. These transformations heavily rely on the in situ generation of reactive rad...
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| Published in | Chemical communications (Cambridge, England) Vol. 54; no. 77; pp. 1791 - 1811 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
25.09.2018
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Over the past years, impressive progress has been made on the development of the chemoselective and direct formation of carbon-carbon and carbon-heteroatom bonds involving internal alkynes under catalytic oxidative systems. These transformations heavily rely on the
in situ
generation of reactive radical intermediates that are initiated by oxidants, visible light photocatalysis, or electrocatalysis and so on. Numerous chemically and biomedically important building blocks have been synthesized, and will continue to be obtained by taking advantage of the radical transformation of internal alkynes in the following years. In this review, we highlight the recent progress in this rapidly growing area by presenting a series of catalytic oxidative reactions, mechanisms and applications which have appeared in the most recent literature.
This review highlights the recent progress in the radical transformation of internal alkynes and focuses on the reaction mechanisms by carbon/heteroatom-centered triggered additions, and offers a comprehensive overview on the existing procedures and employed methodologies. |
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| Bibliography: | Guigen Li was born in 1962 in Jiangsu (China). He received his BS in 1984 and MS in 1987 at Nankai University. He received his PhD in 1995 at University of Arizona with Prof Victor J. Hruby and conducted his postdoctoral research at the Scripps Research Institute with Prof. K. B. Sharpless. He started his independent career at Texas Tech University in 1997. He became Paul Whitfield Horn Professor in 2015, and currently holds an adjunct Distinguished Professor at Nanjing University. His research interests are on establishing new synthetic concepts/technologies, new reagents (chiral and achiral), new methodologies and related mechanisms. Min-Hua Huang was born in 1991 in Jiangsu Province (China). He received his BS in 2015 at Nanjing Tech University. He is currently pursuing his PhD at Nanjing Tech University under the supervision of Prof. De-Cai Wang (from Nanjing Tech University), Prof. Shu-Jiang Tu and Prof. Bo Jiang (from Jiangsu Normal University). His current research interests concern the radical transformation of internal alkynes, radical triggered bicyclization and annulation with bifunctionalization. Shu-Jiang Tu was born in 1957 in Jiangsu (China) and received his BS in 1983 at Jiangsu Normal University. He was appointed as Assistant Professor at the Xuzhou Normal University in 1999 and was promoted to Full Professor in 2003. His current interests are the development of new synthetic methods, green chemistry, and microwave multicomponent syntheses. Bo Jiang was born in 1981 in Jiangsu (China). He received his BS in 2004 and MS in 2007 at Jiangsu Normal University under the supervision of Prof. Shu-Jiang Tu, and his PhD in 2010 at Soochow University with Prof. Shu-Jiang Tu and Prof. Guigen Li. He joined Jiangsu Normal University as a lecturer and is currently a Full Professor. He was as an Associate Research Professor at Texas Tech University from August 2015 to February 2017 in the USA with Prof. Guigen Li. His research interests include asymmetric catalysis, radical transformations, and the innovation of synthetic methods. Wen-Juan Hao was born in 1983 in Jiangsu province, China. She received her BS in 2006 and MS in 2009 at Jiangsu Normal University under the supervision of Prof. Shu-Jiang Tu, her PhD in 2014 at Soochow University with Prof. Shun-Jun Ji and then joined the School of Chemistry and Materials Science at Jiangsu Normal University as a lecturer and is currently an Associate Professor. She was a Visiting Scholar at Nanyang Technological University from July 2016 to January 2017 in Singapore with Prof. Choon Hong Tan. Her research interests include synergistic catalysis, heterocyclic syntheses, and radical domino reactions. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ISSN: | 1359-7345 1364-548X 1364-548X |
| DOI: | 10.1039/c8cc04618b |