Low prebiopsy state irritability scores at the clinical onset of invasive breast carcinoma

• Published in: Journal of psychosomatic research Vol. 56; no. 1; pp. 17 - 26
• Main Authors: Trikas, Panayotis, Vlachonikolis, Ioannis, Askoxilakis, Ioannis, Sanidas, Elias, Tsiftsis, Dimitris, Paritsis, Nicholas
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 2004; New York, NY Elsevier
• Subjects: Adult; Aged; Biological and medical sciences; Biopsy; Biopsy, Needle; Breast; Breast cancer; Breast disorders; Breast Neoplasms - epidemiology; Breast Neoplasms - pathology; Cancer; Carcinoma - pathology; Diagnostic and Statistical Manual of Mental Disorders; Factors; Female; Gynecology. Andrology. Obstetrics; Humans; Irritability; Irritable Mood; Mammary gland diseases; Medical sciences; Menopause - psychology; Mental Disorders - classification; Mental Disorders - diagnosis; Mental Disorders - epidemiology; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Psychopathology; Risk; Risk factors; Screening; Severity of Illness Index; Social Adjustment; Time Factors; Tumors; Breast; Risk; Psychopathology; Biopsy; Factors; Cancer; Human; Breast disease; Carcinoma; Prevalence; Disease; Malignant tumor; Symptomatology; Risk factor; Mental disorder; Female; Diagnosis; Benign neoplasm; Predictive factor; Antecedent; Comparative study; Somatic disease
• ISSN: 0022-3999; 1879-1360
• DOI: 10.1016/S0022-3999(03)00070-9

The research findings regarding the role of psychiatric illness in breast cancer are not yet clear. This report investigates the differences between patients with invasive breast carcinoma (IBC) and patients with benign breast disease regarding the psychiatric history and the current prebiopsy psychopathology. The psychiatric history of 124 females, aged 70 or less, was evaluated by interview and the DSM-IV criteria were used to establish the diagnoses. The Present State Examination (PSE)–Index of Definition (ID)–CATEGO computer program was used to define current psychopathology. Known risk factors of breast cancer were included in the analyses. After biopsy, 59 patients had IBC and 65 had benign breast diseases. Multiple logistic regression analyses showed that low psychiatric history and low irritability were independent predictors of IBC regarding the DSM-IV and the PSE–ID–CATEGO, respectively. Low psychiatric history and low prebiopsy state irritability differentiates IBC patients from noncancer patients.