Triadimefon Disrupts Working Memory in the Matching-to-Position Task

Triadimefon (TDF) is a fungicide which has psychostimulant properties similar to cocaine and amphetamine. Past studies with psychostimulants suggests that acute exposure leads to disruptions in working memory. In this study, we examined the effects of TDF exposure (relative to corn oil control) on p...

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Bibliographic Details
Published inSAGE open Vol. 8; no. 4
Main Authors Holden, John M., Hemmelman, Ethan, McGlasson, Rowan, Smith, Zaria, Ruhland, Ashley, Hoover, Erin
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.10.2018
SAGE PUBLICATIONS, INC
SAGE Publishing
Subjects
Amphetamines
Cocaine
Rodents
retinoic acid
cocaine
working memory
triadimefon
amphetamine
psychostimulant
matching-to-position
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Summary:Triadimefon (TDF) is a fungicide which has psychostimulant properties similar to cocaine and amphetamine. Past studies with psychostimulants suggests that acute exposure leads to disruptions in working memory. In this study, we examined the effects of TDF exposure (relative to corn oil control) on performance in the delayed matching-to-position task in two separate studies using Sprague-Dawley male rats. In both studies, TDF exposure led to significantly poorer performance across delays. TDF shows similar properties to cocaine and amphetamine in terms of disrupting working memory.
ISSN:2158-2440
2158-2440
DOI:10.1177/2158244018805798