An α-Fetoprotein-Producing Hepatoid Adenocarcinoma of the Endometrium

• Published in: Gynecologic oncology Vol. 83; no. 2; pp. 418 - 421
• Main Authors: Adams, S.F., Yamada, S.D., Montag, A., Rotmensch, J.R.
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 01.11.2001; Elsevier
• Subjects: Adenocarcinoma - drug therapy; Adenocarcinoma - metabolism; Adenocarcinoma - pathology; Adenocarcinoma - surgery; Aged; alpha-Fetoproteins - biosynthesis; Biological and medical sciences; Endometrial Neoplasms - drug therapy; Endometrial Neoplasms - metabolism; Endometrial Neoplasms - pathology; Endometrial Neoplasms - surgery; Female; Female genital diseases; Gynecology. Andrology. Obstetrics; Humans; Medical sciences; Neoplasm Staging; Tumors; Human; Adenocarcinoma; Antineoplastic agent; Immunohistochemistry; Process variant; Malignant tumor; Cell differentiation; α-Fetoprotein; Female genital diseases; Case study; Secretory tumor; Pathology; Chemotherapy; Treatment; Hepatocyte; Surgery; Uterine diseases; Adult; Female; Endometrium
• ISSN: 0090-8258; 1095-6859
• DOI: 10.1006/gyno.2001.6383

Background. Hepatoid adenocarcinomas are tumors that arise outside the liver but resemble hepatic tissue and produce α-fetoprotein. These neoplasms have been described in many locations, including the lung, gastrointestinal tract, and urogenital tract, and have been associated with a poor prognosis. Two previously reported cases of hepatoid adenocarcinoma of the endometrium described aggressive tumors that were unresponsive to multiple forms of therapy. Case. We report a case of an α-fetoprotein-producing hepatoid adenocarcinoma of the endometrium that was successfully treated with surgery and adjuvant chemotherapy. Conclusion. Eight years after therapy, the patient is alive with no evidence of disease, suggesting that cytoxan, adriamycin, and cis-platinum are active agents in this unusual entity.