Dorisenones, cytotoxic spongian diterpenoids, from the nudibranch Chromodoris obsoleta

Seven new cytotoxic spongian diterpenoids, dorisenones A ( 1), B ( 2), C ( 3), D ( 4), 7α-hydroxyspongian-16-one ( 5), 15α, 16α-diacetoxy-11, 12β-epoxyspongian ( 6) and 7α-acetoxydendrillol-3 ( 7) were isolated from a Japanese marine mollusk Chromodoris obsoleta (Chromodorididae), together with four...

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Published inTetrahedron Vol. 52; no. 24; pp. 8187 - 8198
Main Authors Miyamoto, Tomofumi, Sakamoto, Kenichiro, Arao, Kazuyoshi, Komori, Tetsuya, Higuchi, Ryuichi, Sasaki, Takuma
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 10.06.1996
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
MARINE NATURAL-PRODUCTS
CONSTITUENTS
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Summary:Seven new cytotoxic spongian diterpenoids, dorisenones A ( 1), B ( 2), C ( 3), D ( 4), 7α-hydroxyspongian-16-one ( 5), 15α, 16α-diacetoxy-11, 12β-epoxyspongian ( 6) and 7α-acetoxydendrillol-3 ( 7) were isolated from a Japanese marine mollusk Chromodoris obsoleta (Chromodorididae), together with four known spongian diterpenoids. Their structures have been elucidated by spectroscopic evidence and single crystal X-ray analysis. Seven new cytotoxic spongian diterpenoids, dorisenones A ( 1), B ( 2), C ( 3), D ( 4), 7α-hydroxyspongian-16-one ( 5), 15α, 16α-diacetoxy-11, 12β-epoxyspongian ( 6) and 7α-acetoxydendrillol-3 ( 7) were isolated from a marine mollusk Chromodoris obsoleta, together with four known spongian diterpenoids.
ISSN:0040-4020
1464-5416
DOI:10.1016/0040-4020(96)00388-2