Association of matrix metalloproteinase-1 gene polymorphism with glioblastoma multiforme in a northern Indian population

Matrix metalloproteinase-1 (MMP-1) is known to be involved in the pathogenesis of glioma. It damages the extra-cellular matrix to produce invasiveness in cancer tissue, and hence has a direct effect in cancer invasion. The study aims to explore the association of single nucleotide polymorphism of -1...

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Published inJournal of neuro-oncology Vol. 102; no. 3; pp. 347 - 352
Main Authors Malik, Nitin, Kumar, Raj, Prasad, Kashi N., Kawal, Priyanka, Srivastava, Arun, Mahapatra, Ashok K.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.05.2011
Springer Nature B.V
Subjects
Adult
Case-Control Studies
Chi-Square Distribution
DNA Mutational Analysis
Female
Gene Frequency
Genetic Predisposition to Disease - genetics
Genotype
Glioblastoma - genetics
Humans
India
Laboratory Investigation - Human/Animal Tissue
Male
Matrix Metalloproteinase 1 - genetics
Medicine
Medicine & Public Health
Middle Aged
Neurology
Oncology
Polymorphism, Genetic - genetics
India
Matrix metalloproteinase-1
Glioblastoma multiforme (GBM)
Glioma
Polymorphism
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Summary:Matrix metalloproteinase-1 (MMP-1) is known to be involved in the pathogenesis of glioma. It damages the extra-cellular matrix to produce invasiveness in cancer tissue, and hence has a direct effect in cancer invasion. The study aims to explore the association of single nucleotide polymorphism of -1607 MMP-1 gene with susceptibility to glioblastoma multiforme (GBM) in northern Indian subjects. One hundred and ten GBM patients and 150 healthy controls were included in this study. 1607 MMP-1 gene was studied by PCR–RFLP; different genotypes being combinations of 1G and 2G allele (1G/1G, 1G/2G and 2G/2G). 2G/2G genotype was significantly associated with GBM patients (OR, 2.24; P  = 0.016; 95% CI, 1.16–4.30) as compared to controls. Prevalence of the 2G allele of -1607 MMP-1 polymorphism was significantly greater in GBM patients as compared to controls (62.3 vs 48.3%, OR, 1.76; P  = 0.002; 95% CI, 1.23–2.52). This study suggests that the 2G/2G genotype and 2G allele of -1607 MMP-1 polymorphism are associated with an increased susceptibility for developing GBM.
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ISSN:0167-594X
1573-7373
1573-7373
DOI:10.1007/s11060-010-0337-z