A Finite Element Model to Investigate the Stability of Osteochondral Grafts Within a Human Tibiofemoral Joint

• Published in: Annals of biomedical engineering Vol. 52; no. 5; pp. 1393 - 1402
• Main Authors: Day, Gavin A., Jones, Alison C., Mengoni, Marlène, Wilcox, Ruth K.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.05.2024; Springer Nature B.V
• Subjects: Autografts; Biochemistry; Biological and Medical Physics; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Biophysics; Bone grafts; Cadavers; Cartilage; Cartilage (articular); Classical Mechanics; Contact pressure; Defects; Finite element method; Grafting; In vitro methods and tests; Investigations; Joints (anatomy); Material properties; Mathematical models; Original Article; Sensitivity analysis; Stability; Knee; Cartilage; Surgical repair; Modelling; Bone; Finite element analysis; Osteoarthritis
• ISSN: 0090-6964; 1573-9686
• DOI: 10.1007/s10439-024-03464-6

Osteochondral grafting has demonstrated positive outcomes for treating articular cartilage defects by replacing the damaged region with a cylindrical graft consisting of bone with a layer of cartilage. However, factors that cause graft subsidence are not well understood. The aim of this study was to develop finite element (FE) models of osteochondral grafts within a tibiofemoral joint, suitable for an investigation of parameters affecting graft stability. Cadaveric femurs were used to experimentally calibrate the bone properties and graft-bone frictional forces for use in corresponding image-based FE models, generated from µCT scan data. Effects of cartilage defects and osteochondral graft repair were measured by examining contact pressure changes using further in vitro tests. Here, six defects were created in the femoral condyles, which were subsequently treated with osteochondral autografts or metal pins. Matching image-based FE models were created, and the contact patches were compared. The bone material properties and graft-bone frictional forces were successfully calibrated from the initial tests with good resulting levels of agreement (CCC = 0.87). The tibiofemoral joint experiment provided a range of cases that were accurately described in the resultant pressure maps and were well represented in the FE models. Cartilage defects and repair quality were experimentally measurable with good agreement in the FE model pressure maps. Model confidence was built through extensive validation and sensitivity testing. It was found that specimen-specific properties were required to accurately represent graft behaviour. The final models produced are suitable for a range of parametric testing to investigate immediate graft stability.