First application of chiral ionic liquids in asymmetric Baylis–Hillman reaction

The first example of the use of chiral ionic liquids as reaction media in the asymmetric Baylis–Hillman reaction was described using N-alkyl- N-methylephedrinium salts. Good yields and significant enantiomeric excesses were obtained. The first example of the use of chiral ionic liquids as reaction m...

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Bibliographic Details
Published inTetrahedron letters Vol. 45; no. 34; pp. 6425 - 6428
Main Authors Pégot, Bruce, Vo-Thanh, Giang, Gori, Didier, Loupy, André
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 16.08.2004
Elsevier
Subjects
Asymmetric synthesis
Baylis–Hillman reaction
Chemistry
Chemistry, Organic
Chirality
Ionic liquids
Physical Sciences
Science & Technology
Ionic liquids
Baylis–Hillman reaction
Asymmetric synthesis
Chirality
PRESSURE
asymmetric synthesis
chirality
SOLVENTS
CARBONYL-COMPOUNDS
BOROHYDRIDE REDUCTION
ionic liquids
INDUCTION
Baylis-Hillman reaction
CATALYSTS
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Summary:The first example of the use of chiral ionic liquids as reaction media in the asymmetric Baylis–Hillman reaction was described using N-alkyl- N-methylephedrinium salts. Good yields and significant enantiomeric excesses were obtained. The first example of the use of chiral ionic liquids as reaction media in the asymmetric Baylis–Hillman reaction was described using N-alkyl- N-methylephedrinium salts. Good yields and significant enantiomeric excesses were obtained.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2004.06.134