Preferential phosphorylation at the primary alcohol of non-protected thymidine or carbohydrates

A preferential phosphorylation at the primary alcohol of non-protected thymidine or carbohydrates by the hydrogen phosphonate method is described. Thus, 6-(mannopyrannosyl), 6-(glucopyrannosyl) or 5′-(thymidinyl) phosphodiesters were obtained in 35% to 80% yields. Examples of preferential phosphoryl...

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Bibliographic Details
Published inTetrahedron letters Vol. 37; no. 29; pp. 5123 - 5126
Main Authors Knerr, Laurent, Pannecoucke, Xavier, Schmitt, Gaby, Luu, Bang
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 15.07.1996
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
7-BETA-HYDROXYCHOLESTEROL
ACID DIESTERS
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Summary:A preferential phosphorylation at the primary alcohol of non-protected thymidine or carbohydrates by the hydrogen phosphonate method is described. Thus, 6-(mannopyrannosyl), 6-(glucopyrannosyl) or 5′-(thymidinyl) phosphodiesters were obtained in 35% to 80% yields. Examples of preferential phosphorylation of primary alcohol by the hydrogen phosphonate method are presented.
ISSN:0040-4039
1873-3581
DOI:10.1016/0040-4039(96)01065-9