Early Surgical Experience with Minimally Invasive Percutaneous Approach for Patients with Metastatic Epidural Spinal Cord Compression (MESCC) to Poor Prognoses

• Published in: Annals of surgical oncology Vol. 19; no. 1; pp. 294 - 300
• Main Authors: Tancioni, Flavio, Navarria, Pierina, Pessina, Federico, Marcheselli, Simona, Rognone, Elisa, Mancosu, Pietro, Santoro, Armando, Baena, Riccardo Rodriguez Y.
• Format: Journal Article
• Language: English
• Published: New York Springer-Verlag 2012; Springer Nature B.V
• Subjects: Adult; Aged; Decompression, Surgical; Feasibility Studies; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Male; Medicine; Medicine & Public Health; Middle Aged; Minimally Invasive Surgical Procedures; Neoplasm Staging; Neoplasms - pathology; Neoplasms - surgery; Neuro-Oncology; Oncology; Prospective Studies; Spinal Cord Compression - prevention & control; Spinal Fractures - prevention & control; Spinal Neoplasms - secondary; Spinal Neoplasms - surgery; Surgery; Surgical Oncology; Treatment Outcome; Invasive Spinal Surgery; Spinal Metastasis; Metastatic Spinal Cord Compression; Body Vertebral Fracture; Minimally Invasive Surgery
• ISSN: 1068-9265; 1534-4681
• DOI: 10.1245/s10434-011-1894-x

Purpose This study was designed to assess the impact of minimally invasive surgery (MIS) for the treatment of patients with metastatic epidural spinal cord compression (MESCC) and vertebral body fracture, in terms of feasibility, clinical improvement, and morbidity. Methods Twenty-five consecutive patients with diagnosis of MESCC from solid primary tumors were treated between January 2008 and June 2010 at our institution. All patients, after multidisciplinary assessment, were considered with poor prognosis because of their disease’s extension and/or other clinical conditions. Mini-invasive percutaneous surgery was performed in all patients followed by radiotherapy within 2 weeks postoperatively. Clinical outcome was evaluated by modified visual analog scale for pain, Frankel Scale for neurologic deficit, and magnetic resonance imaging or computed tomography scan. Results Clinical remission of pain was obtained in the vast majority of patients (96%). Improvement of neurological deficit was observed in 22 patients (88%). No major morbidity or perioperative mortality occurred. The average hospital stay was 6 days. Local recurrence occurred in two patients (8%). Median survival was 10 (range, 6–24) months. Overall survival at 1 year was 43%. Conclusions For patients with MESCC and body fracture, with limited life expectancy, minimally invasive spinal surgery followed by radiotherapy, is feasible and provides clinical benefit in most of patients, with low morbidity. We believe that a minimally invasive approach can be an alternative surgical method compared with more aggressive or demanding procedures, which in selected patients with metastatic spinal cord compression with poor prognosis could represent overtreatment.