Relationship of Family and Personal History to the Occurrence of Depression in Persons With Alzheimer's Disease

The authors tested the associations of family history and personal history of depression with mood disorders among patients with Alzheimer's disease (AD; N = 161). Considered individually, a positive family history and a positive personal history each conferred increased risk for depression in...

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Bibliographic Details
Published inThe American journal of geriatric psychiatry Vol. 9; no. 3; pp. 249 - 254
Main Authors Butt, Zeeshan A., Strauss, Milton E.
Format Journal Article
LanguageEnglish
Published England Elsevier Inc 2001
Subjects
Aged
Alzheimer Disease - psychology
Cognition Disorders - diagnosis
Depressive Disorder, Major - diagnosis
Depressive Disorder, Major - epidemiology
Depressive Disorder, Major - etiology
Family - psychology
Family Relations
Female
Humans
Male
Neuropsychological Tests
Recurrence
Risk Factors
Severity of Illness Index
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Summary:The authors tested the associations of family history and personal history of depression with mood disorders among patients with Alzheimer's disease (AD; N = 161). Considered individually, a positive family history and a positive personal history each conferred increased risk for depression in AD. Conjointly, neither family nor personal history accounted for a substantial amount of the variance in syndromal depression after the onset of AD. Most depressed AD patients in this sample did not have a positive family history or a previous episode of depression. Our understanding of the etiology and course of depression and dementia may be augmented with further neuropsychological and brain-imaging studies of the neuropathological substrates shared by these illnesses.
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ISSN:1064-7481
1545-7214
DOI:10.1097/00019442-200108000-00008