Modulation of the Expression of Immune-related Gene in Atlantic and Coho Salmon during Infestation with the Sea lice Caligus rogercresseyi

Caligus rogercresseyi, a marine ectoparasite, causes notable economic losses for the Chilean salmonid industry. Nevertheless, the immunological responses of infected fish remain poorly understood, including proinflammatory cytokine generation and the respective modulatory effects of various cytokine...

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Bibliographic Details
Published inFishes Vol. 4; no. 3; pp. 42 - 0
Main Authors Pontigo, Juan Pablo, Saravia, Julia, Oyarzún, Ricardo, González, Margarita P., Hawes, Christopher, Morera, Francisco J., Pino, Jorge, Wadsworth, Simon, Muñoz, Jose Luis P., Vargas-Chacoff, Luis
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 2019
Subjects
Aquaculture
Caligus rogercresseyi
Cytokine receptors
Cytokines
Economics
Ectoparasites
Farming
Fish
Freshwater fishes
Gene expression
IL-1β
immune response
Immune system
Infestation
Inflammation
Interleukin 18
Liver
Major histocompatibility complex
Marine fishes
NLRC5
Oncorhynchus kisutch
Parasites
Pathogens
Proteins
Salmo salar
Salmon
sea lice
Vulnerability
Chile
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Summary:Caligus rogercresseyi, a marine ectoparasite, causes notable economic losses for the Chilean salmonid industry. Nevertheless, the immunological responses of infected fish remain poorly understood, including proinflammatory cytokine generation and the respective modulatory effects of various cytokine receptors. This study evaluated mRNA expression of the NLRC5, major histocompatibility complex (MHC) class II, I-kappa-B-alpha, a regulatory that inhibits NF-kappa-B, and proinflammatory cytokines (IL-1β and IL-18) in the liver and muscle of Atlantic salmon (Salmo salar) and Coho salmon (Oncorhynchus kisutch) during a time-course C. rogercresseyi infestation trial. All assessed mRNA were strongly regulated during infestation, but S. salar showed up-regulated expression, possibly accounting for the high infestation vulnerability of this salmonid. In conclusion, this work helps to understand the modulation of the expression of different transcripts involved over short periods of C. rogercresseyi infestation in two salmonid species (S. salar and O. kisutch).
ISSN:2410-3888
2410-3888
DOI:10.3390/fishes4030042