Black Foam Films from Aqueous Solutions of a Mixture of Phospholipids and a Permeation Enhancer

• Published in: Journal of colloid and interface science Vol. 249; no. 2; pp. 398 - 404
• Main Authors: Tranchant, Jean-François, Bonté, Frédéric, Leroy, Sébastien, Nedyalkov, Mickael, Platikanov, Dimo, Javierre, Isabelle, Benattar, Jean-Jacques
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 15.05.2002; Elsevier
• Subjects: bilayers; black films; Chemistry; Colloidal state and disperse state; contact angle; Exact sciences and technology; gas permeability; Gas-liquid interface and liquid-liquid interface; General and physical chemistry; Membranes; skin permeability; Surface physical chemistry; surface tension; x-ray reflectivity; black films; gas permeability; bilayers; contact angle; x-ray reflectivity; surface tension; skin permeability; Electrolyte solution; Film; Permeation; Phospholipid; Lipids; Contact angle; Experimental study; Sodium chloride; Bilayer; Ketone; Layer thickness; Gas permeability; X ray reflection; Surface tension; Aqueous solution; Oxygen nitrogen heterocycle
• ISSN: 0021-9797; 1095-7103
• DOI: 10.1006/jcis.2002.8308

The influence of a permeation enhancer on the properties of phospholipid black foam films has been studied through the combination of three complementary techniques: surface tension measurements, X-ray reflectivity, and the “diminishing bubble” method. This permeation enhancer is said to optimize the delivery of active ingredients into or through the stratum corneum: the 4-decyl oxazolidin-2-one. We made films of a complex phospholipid mixture that mimic the behavior of the enhancer in a membrane cell. Mixed phospholipids/4-decyl oxazolidin-2-one/NaCl solutions were studied with various 4-decyl oxazolidin-2-one concentrations. Stable black films were obtained and their thicknesses examined. The evolution of the coefficient of gas permeability with 4-decyl oxazolidin-2-one concentration is also addressed.