Treatment of Inflammatory Bowel Disease with Chinese Drugs Administered by Both Oral Intake and Retention Enema

• Published in: Chinese journal of integrative medicine Vol. 16; no. 3; pp. 222 - 228
• Main Author: 凌霄华 于欣 孔德军 胡成乙 洪钰 杨小明
• Format: Journal Article
• Language: English
• Published: Heidelberg Chinese Association of Traditional and Western Medicine 01.06.2010
• Subjects: Administration, Oral; Adult; Colon - drug effects; Colon - pathology; Colonoscopy; Drugs, Chinese Herbal - administration & dosage; Drugs, Chinese Herbal - pharmacology; Drugs, Chinese Herbal - therapeutic use; Enema; Humans; Inflammatory Bowel Diseases - drug therapy; Inflammatory Bowel Diseases - pathology; Medicine; Medicine & Public Health; Middle Aged; Original Article; Treatment Outcome; Young Adult; 中药; 临床效果; 口语; 摄入量; 灌肠治疗; 炎症; 组织病理学; 药品管理; clinical study; retention enema; outer-inner combined therapy; inflammatory bowel disease
• ISSN: 1672-0415; 1993-0402; 1993-0402
• DOI: 10.1007/s11655-010-0222-0

Objective：To study the clinical effect of Chinese drugs administered by both oral intake and retention enema on inflammatory bowel diseases（IBD）.Methods：Adopting a randomized controlled design,78 patients were assigned to three groups：26 patients in group A treated with Chinese drugs given by both oral intake and retention enema,27 in group B with Chinese drugs given by retention enema only,and 25 in group C with given Western medicine.The changes before and after a 30-day treatment of the patients＇ symptoms （including diarrhea,abdominal pain,mucous or pus-bloody stool）,colonoscopic examination scores and histopathology of the colonic membrane were observed.Results：Group A showed the best outcomes in all the aspects of clinical comprehensive effectiveness.Improvements in the main symptoms,colonoscopic scores and histopathology of the colonic membrane were significantly different from those in groups B and C,respectively （P〈0.05）.Meanwhile comparisons between groups B and C showed insignificant differences（P〉0.05）; group B was better in ameliorating tenesmus（P〈0.05）.Conclusion：Through the use of Chinese drugs administered by both oral intake and retention enema to treat IBD,which combined external-internal therapies for both overall regulation and local managment,it was confirmed that the Chinese medicine could embody the therapeutic principle of attending to both disease-diagnosis and syndrome-differentiation.