Lack of Alpha-Synuclein Modulates Microglial Phenotype In Vitro
Alpha (α)-synuclein neuronal effects are continually being defined although its role in regulating glial phenotypes remains unclear. An ability to regulate microglial activation was investigated using primary cultures from wild type and α-synuclein deficient mice ( Snca − / − ). Snca − / − microglia...
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| Published in | Neurochemical research Vol. 36; no. 6; pp. 994 - 1004 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Boston
Springer US
01.06.2011
Springer Nature B.V |
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| Online Access | Get full text |
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| Abstract | Alpha (α)-synuclein neuronal effects are continually being defined although its role in regulating glial phenotypes remains unclear. An ability to regulate microglial activation was investigated using primary cultures from wild type and α-synuclein deficient mice (
Snca
−
/
−
).
Snca
−
/
−
microglia demonstrated increased secretion of the cytokine tumor necrosis factor-alpha (TNF-α), impaired phagocytic ability, elevated prostaglandin levels, and increased protein levels of key enzymes in lipid-mediated signaling events, cytosolic phospholipase (cPLA
2
), cyclooxygenase-2 (Cox-2) and phospholipase D2 (PLD2) when compared to wild type cells. Increased cytokine secretion and cPLA
2
and Cox-2 levels in
Snca
−
/
−
microglia were partially attenuated by inhibiting PLD-dependent signaling with n-butanol treatment. |
|---|---|
| AbstractList | Alpha (α)-synuclein neuronal effects are continually being defined although its role in regulating glial phenotypes remains unclear. An ability to regulate microglial activation was investigated using primary cultures from wild type and α-synuclein deficient mice (Snca-/-). Snca-/- microglia demonstrated increased secretion of the cytokine tumor necrosis factor-alpha (TNF-α), impaired phagocytic ability, elevated prostaglandin levels, and increased protein levels of key enzymes in lipid-mediated signaling events, cytosolic phospholipase (cPLA(2)), cyclooxygenase-2 (Cox-2) and phospholipase D2 (PLD2) when compared to wild type cells. Increased cytokine secretion and cPLA(2) and Cox-2 levels in Snca-/- microglia were partially attenuated by inhibiting PLD-dependent signaling with n-butanol treatment. Alpha (α)-synuclein neuronal effects are continually being defined although its role in regulating glial phenotypes remains unclear. An ability to regulate microglial activation was investigated using primary cultures from wild type and α-synuclein deficient mice (Snca ^sup -/-^). Snca ^sup -/-^ microglia demonstrated increased secretion of the cytokine tumor necrosis factor-alpha (TNF-α), impaired phagocytic ability, elevated prostaglandin levels, and increased protein levels of key enzymes in lipid-mediated signaling events, cytosolic phospholipase (cPLA^sub 2^), cyclooxygenase-2 (Cox-2) and phospholipase D2 (PLD2) when compared to wild type cells. Increased cytokine secretion and cPLA^sub 2^ and Cox-2 levels in Snca ^sup -/-^ microglia were partially attenuated by inhibiting PLD-dependent signaling with n-butanol treatment.[PUBLICATION ABSTRACT] Alpha (α)-synuclein neuronal effects are continually being defined although its role in regulating glial phenotypes remains unclear. An ability to regulate microglial activation was investigated using primary cultures from wild type and α-synuclein deficient mice ( Snca − / − ). Snca − / − microglia demonstrated increased secretion of the cytokine tumor necrosis factor-alpha (TNF-α), impaired phagocytic ability, elevated prostaglandin levels, and increased protein levels of key enzymes in lipid-mediated signaling events, cytosolic phospholipase (cPLA 2 ), cyclooxygenase-2 (Cox-2) and phospholipase D2 (PLD2) when compared to wild type cells. Increased cytokine secretion and cPLA 2 and Cox-2 levels in Snca − / − microglia were partially attenuated by inhibiting PLD-dependent signaling with n-butanol treatment. |
| Author | Golovko, Mikhail Y. Murphy, Eric J. Rojanathammanee, Lalida Austin, Susan A. Combs, Colin K. |
| Author_xml | – sequence: 1 givenname: Susan A. surname: Austin fullname: Austin, Susan A. organization: Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, School of Medicine and Health Sciences – sequence: 2 givenname: Lalida surname: Rojanathammanee fullname: Rojanathammanee, Lalida organization: Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, School of Medicine and Health Sciences – sequence: 3 givenname: Mikhail Y. surname: Golovko fullname: Golovko, Mikhail Y. organization: Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences – sequence: 4 givenname: Eric J. surname: Murphy fullname: Murphy, Eric J. organization: Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences – sequence: 5 givenname: Colin K. surname: Combs fullname: Combs, Colin K. email: ccombs@medicine.nodak.edu organization: Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, School of Medicine and Health Sciences |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21384098$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1042/0264-6021:3580119 10.1021/bi900114z 10.1111/j.1432-1033.1993.tb17686.x 10.1016/j.bcp.2009.09.026 10.1021/bi052344d 10.1111/j.1471-4159.2006.04348.x 10.1016/j.jneuroim.2009.09.004 10.1016/0006-8993(93)90796-P 10.1007/s11481-009-9176-0 10.1016/j.toxlet.2003.09.009 10.1016/j.bbrc.2009.02.002 10.1074/jbc.M605965200 10.1186/1742-2094-2-14 10.1194/jlr.D700030-JLR200 10.1007/s00441-004-0944-0 10.1016/j.parkreldis.2004.01.005 10.1111/j.1471-4159.2005.03247.x 10.1523/JNEUROSCI.0692-05.2005 10.1111/j.1600-0854.2008.00853.x 10.1126/science.1090439 10.1007/s11010-008-0008-y 10.1021/bi901723p 10.1016/j.neurobiolaging.2006.11.013 10.1038/ng0298-106 10.1111/j.1749-6632.2002.tb04856.x 10.1016/0014-5793(96)01056-3 10.1016/j.jmb.2004.02.014 10.1523/JNEUROSCI.6202-08.2009 10.1073/pnas.0710685105 10.1186/1742-2094-4-2 10.1074/jbc.M313747200 10.1046/j.1471-4159.2000.0751053.x 10.1074/jbc.M500984200 10.1021/bi0600289 10.1074/jbc.M004851200 10.1038/35043117 10.1111/j.1471-4159.2005.03145.x 10.4049/jimmunol.0803982 10.1002/glia.20532 10.1523/JNEUROSCI.1799-06.2006 10.1111/j.1471-4159.2006.04357.x 10.1016/S1474-4422(03)00481-2 10.1016/j.neulet.2007.12.031 10.1523/JNEUROSCI.3821-06.2006 10.1111/j.1471-4159.2009.06075.x 10.1186/1742-2094-7-22 10.1016/j.neurobiolaging.2008.10.013 10.1371/journal.pone.0008784 10.2174/187152809789352249 10.1111/j.1600-0854.2006.00389.x 10.1111/j.1460-9568.1997.tb01444.x 10.1002/1097-4547(20001001)62:1<9::AID-JNR2>3.0.CO;2-U 10.1074/jbc.M110414200 10.1096/fj.06-6183com 10.1126/science.276.5321.2045 10.1021/bi972776r 10.1038/nrm1315 10.1126/science.1090278 10.1096/fj.04-2751com 10.1021/bi0502137 10.1016/j.neurobiolaging.2007.04.006 10.1016/j.brainres.2010.01.086 10.1016/S1567-5769(01)00069-8 10.1111/j.1471-4159.2006.04330.x 10.1523/JNEUROSCI.22-20-08797.2002 10.1523/JNEUROSCI.08-08-02804.1988 10.1016/j.bbalip.2008.03.005 10.1523/JNEUROSCI.20-09-03214.2000 10.4049/jimmunol.180.9.6027 10.1042/bj3220353 10.4049/jimmunol.173.4.2615 10.4049/jimmunol.163.10.5462 10.1177/039463200902200405 10.1523/JNEUROSCI.21-04-01179.2001 |
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| References | Kruger, Kuhn, Muller, Woitalla, Graeber, Kosel, Przuntek, Epplen, Schols, Riess (CR74) 1998; 18 Barcelo-Coblijn, Golovko, Weinhofer, Berger, Murphy (CR32) 2007; 101 Ock, Kim, Yi, Kim, Han, Cho, Suk (CR69) 2010; 79 Mori (CR15) 2002; 977 Perrin, Woods, Clayton, George (CR37) 2000; 275 Jin, Shie, Liu, Wang, Davis, Schantz, Montine, Montine, Zhang (CR51) 2007; 4 Liu, Zhang, Shi, Quinn, Bradner, Beyer, Chen, Zhang (CR63) 2009; 29 Yang, Du, Tang, Jung, Zheng, Soh, Kim, Gu, Park (CR67) 2009; 216 Lee, Park, Ahn, Chung, Paik, Kim (CR44) 2009; 381 Austin, Floden, Murphy, Combs (CR17) 2006; 26 Kim, Cho, Kim, Shin, Kim, Park, Chang, Lee, Cho, Suh (CR18) 2009; 109 Murphy, Rueter, Trojanowski, Lee (CR8) 2000; 20 Zhang, Dallas, Zhang, Guo, Pang, Wilson, Miller, Chen, McGeer, Hong, Zhang (CR48) 2007; 55 Zhang, Zhao, Dong (CR19) 2001; 1 Hamdi, Cariven, Coronas, Malet, Chap, Perret, Salles, Record (CR41) 2008; 1781 Gitler, Bevis, Shorter, Strathearn, Hamamichi, Su, Caldwell, Caldwell, Rochet, McCaffery, Barlowe, Lindquist (CR2) 2008; 105 Kirchhausen (CR62) 2000; 1 Croisier, Moran, Dexter, Pearce, Graeber (CR72) 2005; 2 Iyer, Barton, Bourgoin, Kusner (CR22) 2004; 173 Klegeris, Giasson, Zhang, Maguire, Pelech, McGeer (CR50) 2006; 20 Golovko, Faergeman, Cole, Castagnet, Nussbaum, Murphy (CR10) 2005; 44 Sugama, Takenouchi, Cho, Joh, Hashimoto, Kitani (CR68) 2009; 8 El-Agnaf, Walsh, Allsop (CR53) 2003; 2 Sondag, Combs (CR28) 2010; 7 Teismann, Schulz (CR71) 2004; 318 Golovko, Rosenberger, Faergeman, Feddersen, Cole, Pribill, Berger, Nussbaum, Murphy (CR34) 2006; 45 Cabin, Shimazu, Murphy, Cole, Gottschalk, McIlwain, Orrison, Chen, Ellis, Paylor, Lu, Nussbaum (CR26) 2002; 22 Bodner, Maltsev, Dobson, Bax (CR35) 2010; 49 Nagano, Kimura, Takemura (CR65) 2010; 1323 Lee, Patel, Lee (CR54) 2005; 25 Castagnet, Golovko, Barcelo-Coblijn, Nussbaum, Murphy (CR9) 2005; 94 Meulener, Graves, Sampathu, Armstrong-Gold, Bonini, Giasson (CR7) 2005; 93 Gomez-Cambronero, Horwitz, Sha’afi (CR60) 2003; 218 Shibayama-Imazu, Okahashi, Omata, Nakajo, Ochiai, Nakai, Hama, Nakamura, Nakaya (CR4) 1993; 622 Jenco, Rawlingson, Daniels, Morris (CR23) 1998; 37 Sanchez-Guajardo, Febbraro, Kirik, Romero-Ramos (CR52) 2010; 5 Golovko, Rosenberger, Feddersen, Faergeman, Murphy (CR33) 2007; 101 Payton, Perrin, Woods, George (CR25) 2004; 337 Maroteaux, Campanelli, Scheller (CR3) 1988; 8 Minghetti, Polazzi, Nicolini, Creminon, Levi (CR64) 1997; 9 Richter-Landsberg, Gorath, Trojanowski, Lee (CR14) 2000; 62 Sondag, Combs (CR29) 2004; 279 Lee, Lee, Han, Kim, Kim, Suh, Ryu (CR40) 2000; 75 Zhang, Wang, Pei, Miller, Wu, Block, Wilson, Zhou, Hong, Zhang (CR47) 2005; 19 Ben Gedalya, Loeb, Israeli, Altschuler, Selkoe, Sharon (CR66) 2009; 10 Golovko, Murphy (CR12) 2008; 432 De Valck, Beyaert, Van Roy, Fiers (CR21) 1993; 212 Austin, Combs (CR30) 2008; 31 Cheng, Trombetta (CR16) 2004; 146 Maxfield, McGraw (CR61) 2004; 5 Combs, Karlo, Kao, Landreth (CR42) 2001; 21 Peng, Stevenson, Doctrow, Andersen (CR6) 2005; 280 Golovko, Murphy (CR31) 2008; 49 McGeer, McGeer (CR70) 2004; 10 Wislet-Gendebien, D’Souza, Kawarai, St George-Hyslop, Westaway, Fraser, Tandon (CR13) 2006; 281 Klegeris, Pelech, Giasson, Maguire, Zhang, McGeer, McGeer (CR49) 2008; 29 Reynolds, Stone, Mosley, Gendelman (CR45) 2009; 182 Trexler, Rhoades (CR36) 2009; 48 Fujita, Murakami, Yamashita, Amemiya, Kudo (CR38) 1996; 395 Singleton, Farrer, Johnson, Singleton, Hague, Kachergus, Hulihan, Peuralinna, Dutra, Nussbaum, Lincoln, Crawley, Hanson, Maraganore, Adler, Cookson, Muenter, Baptista, Miller, Blancato, Hardy, Gwinn-Hardy (CR75) 2003; 302 Larsen, Schmitz, Troyer, Mosharov, Dietrich, Quazi, Savalle, Nemani, Chaudhry, Edwards, Stefanis, Sulzer (CR1) 2006; 26 Outeiro, Lindquist (CR24) 2003; 302 Sethu, Mendez-Corao, Melendez (CR20) 2008; 180 Su, Maguire-Zeiss, Giuliano, Prifti, Venkatesh, Federoff (CR46) 2008; 29 Corrotte, Chasserot-Golaz, Huang, Du, Ktistakis, Frohman, Vitale, Bader, Grant (CR59) 2006; 7 Ahn, Rhim, Kim, Sung, Lee, Choi, Wolozin, Chang, Lee, Kwon, Chung, Yoon, Hahn, Kim, Jo, Min (CR5) 2002; 277 Locati, Riboldi, Bonecchi, Transidico, Bernasconi, Haribabu, Morris, Mantovani, Sozzani (CR57) 2001; 358 Wilms, Rosenstiel, Romero-Ramos, Arlt, Schafer, Seegert, Kahle, Odoy, Claasen, Holzknecht, Brandenburg, Deuschl, Schreiber, Kirik, Lucius (CR43) 2009; 22 Polymeropoulos, Lavedan, Leroy, Ide, Dehejia, Dutra, Pike, Root, Rubenstein, Boyer, Stenroos, Chandrasekharappa, Athanassiadou, Papapetropoulos, Johnson, Lazzarini, Duvoisin, Di Iorio, Golbe, Nussbaum (CR73) 1997; 276 Jara, Singh, Floden, Combs (CR27) 2007; 100 Lee, Tran, Tansey (CR55) 2009; 4 Golovko, Barcelo-Coblijn, Castagnet, Austin, Combs, Murphy (CR11) 2009; 326 Kim, Lee, Kim, Lee, Suh, Ryu (CR58) 1999; 163 Bauldry, Wooten (CR39) 1997; 322 Ramakrishnan, Jensen, Marsh (CR56) 2006; 45 16519533 - Biochemistry. 2006 Mar 14;45(10):3386-95 11252894 - Nat Rev Mol Cell Biol. 2000 Dec;1(3):187-98 19193894 - J Neurosci. 2009 Feb 4;29(5):1480-5 8898114 - FEBS Lett. 1996 Oct 21;395(2-3):293-8 17012252 - FASEB J. 2006 Oct;20(12):2000-8 17537546 - Neurobiol Aging. 2008 Nov;29(11):1690-701 12388586 - J Neurosci. 2002 Oct 15;22(20):8797-807 17204153 - J Neuroinflammation. 2007 Jan 04;4:2 14593171 - Science. 2003 Oct 31;302(5646):841 18162536 - Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):145-50 15791003 - FASEB J. 2005 Apr;19(6):533-42 10777786 - J Neurosci. 2000 May 1;20(9):3214-20 19815299 - J Neuroimmunol. 2009 Nov 30;216(1-2):32-8 15946937 - J Biol Chem. 2005 Aug 12;280(32):29194-8 19351591 - Biochem Biophys Res Commun. 2009 Mar 27;381(1):39-43 11002283 - J Neurosci Res. 2000 Oct 1;62(1):9-14 9065750 - Biochem J. 1997 Mar 1;322 ( Pt 2):353-63 15935068 - J Neurochem. 2005 Jun;93(6):1524-32 18424723 - J Immunol. 2008 May 1;180(9):6027-34 14657500 - Science. 2003 Dec 5;302(5651):1772-5 17250686 - J Neurochem. 2007 Apr;101(1):132-41 16497229 - Traffic. 2006 Mar;7(3):365-77 15033366 - J Mol Biol. 2004 Apr 2;337(4):1001-9 17166628 - Neurobiol Aging. 2008 May;29(5):739-52 15976091 - J Neurosci. 2005 Jun 22;25(25):6016-24 19058878 - Neurobiol Aging. 2010 Nov;31(11):1854-66 12480791 - Ann N Y Acad Sci. 2002 Nov;977:493-500 19299711 - J Immunol. 2009 Apr 1;182(7):4137-49 18226447 - Neurosci Lett. 2008 Feb 27;432(3):243-7 19800321 - Biochem Pharmacol. 2010 Feb 15;79(4):596-609 12616720 - Methods Mol Biol. 2003;218:155-76 15109580 - Parkinsonism Relat Disord. 2004 May;10 Suppl 1:S3-7 17600340 - Glia. 2007 Aug 15;55(11):1178-88 3411354 - J Neurosci. 1988 Aug;8(8):2804-15 10952980 - J Biol Chem. 2000 Nov 3;275(44):34393-8 15040445 - Nat Rev Mol Cell Biol. 2004 Feb;5(2):121-32 11460317 - Int Immunopharmacol. 2001 Jul;1(7):1375-84 18423386 - Biochim Biophys Acta. 2008 May;1781(5):263-9 15938614 - Biochemistry. 2005 Jun 14;44(23):8251-9 16033426 - J Neurochem. 2005 Aug;94(3):839-49 19220042 - Biochemistry. 2009 Mar 24;48(11):2304-6 19754411 - Inflamm Allergy Drug Targets. 2009 Sep;8(4):277-84 9462735 - Nat Genet. 1998 Feb;18(2):106-8 9538008 - Biochemistry. 1998 Apr 7;37(14):4901-9 7694766 - Brain Res. 1993 Sep 17;622(1-2):17-25 14732706 - J Biol Chem. 2004 Apr 2;279(14):14456-63 8444187 - Eur J Biochem. 1993 Mar 1;212(2):491-7 10553072 - J Immunol. 1999 Nov 15;163(10 ):5462-70 19821032 - J Neuroimmune Pharmacol. 2009 Dec;4(4):419-29 19457162 - J Neurochem. 2009 Jun;109(5):1483-96 16926154 - J Biol Chem. 2006 Oct 27;281(43):32148-55 12878433 - Lancet Neurol. 2003 Aug;2(8):461-2 17035541 - J Neurosci. 2006 Oct 11;26(41):10558-63 11821392 - J Biol Chem. 2002 Apr 5;277(14):12334-42 15935098 - J Neuroinflammation. 2005 Jun 03;2:14 15294978 - J Immunol. 2004 Aug 15;173(4):2615-23 20302643 - J Neuroinflammation. 2010 Mar 19;7:22 14643966 - Toxicol Lett. 2004 Jan 15;146(2):139-49 20144888 - Brain Res. 2010 Apr 6;1323:11-7 11485559 - Biochem J. 2001 Aug 15;358(Pt 1):119-25 20074453 - Int J Immunopathol Pharmacol. 2009 Oct-Dec;22(4):897-909 16734431 - Biochemistry. 2006 Jun 6;45(22):6956-66 20041693 - Biochemistry. 2010 Feb 9;49(5):862-71 9182946 - Eur J Neurosci. 1997 May;9(5):934-40 17241124 - J Neurochem. 2007 Mar;100(5):1407-20 18187404 - J Lipid Res. 2008 Apr;49(4):893-902 18980610 - Traffic. 2009 Feb;10(2):218-34 15338271 - Cell Tissue Res. 2004 Oct;318(1):149-61 19116775 - Mol Cell Biochem. 2009 Jun;326(1-2):55-66 11160388 - J Neurosci. 2001 Feb 15;21(4):1179-88 17108165 - J Neurosci. 2006 Nov 15;26(46):11915-22 9197268 - Science. 1997 Jun 27;276(5321):2045-7 17250657 - J Neurochem. 2007 Apr;101(1):201-11 10936186 - J Neurochem. 2000 Sep;75(3):1053-9 20098715 - PLoS One. 2010 Jan 20;5(1):e8784 MY Golovko (439_CR34) 2006; 45 JM Jenco (439_CR23) 1998; 37 L Maroteaux (439_CR3) 1988; 8 M Corrotte (439_CR59) 2006; 7 J Liu (439_CR63) 2009; 29 KE Larsen (439_CR1) 2006; 26 CR Bodner (439_CR35) 2010; 49 AD Gitler (439_CR2) 2008; 105 AD Reynolds (439_CR45) 2009; 182 SM Hamdi (439_CR41) 2008; 1781 JH Jara (439_CR27) 2007; 100 SB Lee (439_CR44) 2009; 381 SA Bauldry (439_CR39) 1997; 322 AB Singleton (439_CR75) 2003; 302 X Su (439_CR46) 2008; 29 S Mori (439_CR15) 2002; 977 T Kirchhausen (439_CR62) 2000; 1 CM Sondag (439_CR29) 2004; 279 MY Golovko (439_CR33) 2007; 101 J Jin (439_CR51) 2007; 4 T Nagano (439_CR65) 2010; 1323 RJ Perrin (439_CR37) 2000; 275 OM El-Agnaf (439_CR53) 2003; 2 A Klegeris (439_CR49) 2008; 29 A Klegeris (439_CR50) 2006; 20 V Sanchez-Guajardo (439_CR52) 2010; 5 SY Cheng (439_CR16) 2004; 146 DD Murphy (439_CR8) 2000; 20 JK Lee (439_CR55) 2009; 4 M Locati (439_CR57) 2001; 358 SD Lee (439_CR40) 2000; 75 J Ock (439_CR69) 2010; 79 SS Iyer (439_CR22) 2004; 173 CK Combs (439_CR42) 2001; 21 PI Castagnet (439_CR9) 2005; 94 JE Payton (439_CR25) 2004; 337 W Zhang (439_CR47) 2005; 19 MY Golovko (439_CR12) 2008; 432 S Sethu (439_CR20) 2008; 180 DE Cabin (439_CR26) 2002; 22 K Fujita (439_CR38) 1996; 395 T Shibayama-Imazu (439_CR4) 1993; 622 H Wilms (439_CR43) 2009; 22 MY Golovko (439_CR10) 2005; 44 SA Austin (439_CR17) 2006; 26 D Valck De (439_CR21) 1993; 212 C Richter-Landsberg (439_CR14) 2000; 62 S Sugama (439_CR68) 2009; 8 MH Polymeropoulos (439_CR73) 1997; 276 TF Outeiro (439_CR24) 2003; 302 M Ramakrishnan (439_CR56) 2006; 45 E Croisier (439_CR72) 2005; 2 MY Golovko (439_CR11) 2009; 326 T Ben Gedalya (439_CR66) 2009; 10 X Yang (439_CR67) 2009; 216 S Wislet-Gendebien (439_CR13) 2006; 281 MY Golovko (439_CR31) 2008; 49 S Kim (439_CR18) 2009; 109 L Minghetti (439_CR64) 1997; 9 BH Ahn (439_CR5) 2002; 277 PL McGeer (439_CR70) 2004; 10 J Peng (439_CR6) 2005; 280 F Zhang (439_CR19) 2001; 1 G Barcelo-Coblijn (439_CR32) 2007; 101 JH Kim (439_CR58) 1999; 163 HJ Lee (439_CR54) 2005; 25 AJ Trexler (439_CR36) 2009; 48 MC Meulener (439_CR7) 2005; 93 SA Austin (439_CR30) 2008; 31 J Gomez-Cambronero (439_CR60) 2003; 218 P Teismann (439_CR71) 2004; 318 CM Sondag (439_CR28) 2010; 7 W Zhang (439_CR48) 2007; 55 R Kruger (439_CR74) 1998; 18 FR Maxfield (439_CR61) 2004; 5 |
| References_xml | – volume: 358 start-page: 119 year: 2001 end-page: 125 ident: CR57 article-title: Selective induction of phospholipase D1 in pathogen-activated human monocytes publication-title: Biochem J doi: 10.1042/0264-6021:3580119 contributor: fullname: Sozzani – volume: 48 start-page: 2304 year: 2009 end-page: 2306 ident: CR36 article-title: Alpha-synuclein binds large unilamellar vesicles as an extended helix publication-title: Biochemistry doi: 10.1021/bi900114z contributor: fullname: Rhoades – volume: 212 start-page: 491 year: 1993 end-page: 497 ident: CR21 article-title: Tumor necrosis factor cytotoxicity is associated with phospholipase D activation publication-title: Eur J Biochem doi: 10.1111/j.1432-1033.1993.tb17686.x contributor: fullname: Fiers – volume: 79 start-page: 596 year: 2010 end-page: 609 ident: CR69 article-title: A novel anti-neuroinflammatory pyridylimidazole compound KR-31360 publication-title: Biochem Pharmacol doi: 10.1016/j.bcp.2009.09.026 contributor: fullname: Suk – volume: 45 start-page: 3386 year: 2006 end-page: 3395 ident: CR56 article-title: Association of alpha-synuclein and mutants with lipid membranes: spin-label ESR and polarized IR publication-title: Biochemistry doi: 10.1021/bi052344d contributor: fullname: Marsh – volume: 101 start-page: 132 year: 2007 end-page: 141 ident: CR32 article-title: Brain neutral lipids mass is increased in alpha-synuclein gene-ablated mice publication-title: J Neurochem doi: 10.1111/j.1471-4159.2006.04348.x contributor: fullname: Murphy – volume: 216 start-page: 32 year: 2009 end-page: 38 ident: CR67 article-title: Brevicompanine E reduces lipopolysaccharide-induced production of proinflammatory cytokines and enzymes in microglia by inhibiting activation of activator protein-1 and nuclear factor-kappaB publication-title: J Neuroimmunol doi: 10.1016/j.jneuroim.2009.09.004 contributor: fullname: Park – volume: 622 start-page: 17 year: 1993 end-page: 25 ident: CR4 article-title: Cell and tissue distribution and developmental change of neuron specific 14 kDa protein (phosphoneuroprotein 14) publication-title: Brain Res doi: 10.1016/0006-8993(93)90796-P contributor: fullname: Nakaya – volume: 4 start-page: 419 year: 2009 end-page: 429 ident: CR55 article-title: Neuroinflammation in Parkinson’s disease publication-title: J Neuroimmune Pharmacol doi: 10.1007/s11481-009-9176-0 contributor: fullname: Tansey – volume: 163 start-page: 5462 year: 1999 end-page: 5470 ident: CR58 article-title: Cytosolic phospholipase A2-mediated regulation of phospholipase D2 in leukocyte cell lines publication-title: J Immunol contributor: fullname: Ryu – volume: 146 start-page: 139 year: 2004 end-page: 149 ident: CR16 article-title: The induction of amyloid precursor protein and alpha-synuclein in rat hippocampal astrocytes by diethyldithiocarbamate and copper with or without glutathione publication-title: Toxicol Lett doi: 10.1016/j.toxlet.2003.09.009 contributor: fullname: Trombetta – volume: 381 start-page: 39 year: 2009 end-page: 43 ident: CR44 article-title: Identification of the amino acid sequence motif of alpha-synuclein responsible for macrophage activation publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2009.02.002 contributor: fullname: Kim – volume: 281 start-page: 32148 year: 2006 end-page: 32155 ident: CR13 article-title: Cytosolic proteins regulate alpha-synuclein dissociation from presynaptic membranes publication-title: J Biol Chem doi: 10.1074/jbc.M605965200 contributor: fullname: Tandon – volume: 2 start-page: 14 year: 2005 ident: CR72 article-title: Microglial inflammation in the parkinsonian substantia nigra: relationship to alpha-synuclein deposition publication-title: J Neuroinflammation doi: 10.1186/1742-2094-2-14 contributor: fullname: Graeber – volume: 22 start-page: 8797 year: 2002 end-page: 8807 ident: CR26 article-title: Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein publication-title: J Neurosci contributor: fullname: Nussbaum – volume: 49 start-page: 893 year: 2008 end-page: 902 ident: CR31 article-title: An improved LC-MS/MS procedure for brain prostanoid analysis using brain fixation with head-focused microwave irradiation and liquid-liquid extraction publication-title: J Lipid Res doi: 10.1194/jlr.D700030-JLR200 contributor: fullname: Murphy – volume: 318 start-page: 149 year: 2004 end-page: 161 ident: CR71 article-title: Cellular pathology of Parkinson’s disease: astrocytes, microglia and inflammation publication-title: Cell Tissue Res doi: 10.1007/s00441-004-0944-0 contributor: fullname: Schulz – volume: 10 start-page: S3 issue: Suppl 1 year: 2004 end-page: S7 ident: CR70 article-title: Inflammation and neurodegeneration in Parkinson’s disease publication-title: Parkinsonism Relat Disord doi: 10.1016/j.parkreldis.2004.01.005 contributor: fullname: McGeer – volume: 20 start-page: 3214 year: 2000 end-page: 3220 ident: CR8 article-title: Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons publication-title: J Neurosci contributor: fullname: Lee – volume: 94 start-page: 839 year: 2005 end-page: 849 ident: CR9 article-title: Fatty acid incorporation is decreased in astrocytes cultured from alpha-synuclein gene-ablated mice publication-title: J Neurochem doi: 10.1111/j.1471-4159.2005.03247.x contributor: fullname: Murphy – volume: 25 start-page: 6016 year: 2005 end-page: 6024 ident: CR54 article-title: Intravesicular localization and exocytosis of alpha-synuclein and its aggregates publication-title: J Neurosci doi: 10.1523/JNEUROSCI.0692-05.2005 contributor: fullname: Lee – volume: 10 start-page: 218 year: 2009 end-page: 234 ident: CR66 article-title: Alpha-synuclein and polyunsaturated fatty acids promote clathrin-mediated endocytosis and synaptic vesicle recycling publication-title: Traffic doi: 10.1111/j.1600-0854.2008.00853.x contributor: fullname: Sharon – volume: 302 start-page: 1772 year: 2003 end-page: 1775 ident: CR24 article-title: Yeast cells provide insight into alpha-synuclein biology and pathobiology publication-title: Science doi: 10.1126/science.1090439 contributor: fullname: Lindquist – volume: 22 start-page: 897 year: 2009 end-page: 909 ident: CR43 article-title: Suppression of MAP kinases inhibits microglial activation and attenuates neuronal cell death induced by alpha-synuclein protofibrils publication-title: Int J Immunopathol Pharmacol contributor: fullname: Lucius – volume: 326 start-page: 55 year: 2009 end-page: 66 ident: CR11 article-title: The role of alpha-synuclein in brain lipid metabolism: a downstream impact on brain inflammatory response publication-title: Mol Cell Biochem doi: 10.1007/s11010-008-0008-y contributor: fullname: Murphy – volume: 49 start-page: 862 year: 2010 end-page: 871 ident: CR35 article-title: Differential phospholipid binding of alpha-synuclein variants implicated in Parkinson’s disease revealed by solution NMR spectroscopy publication-title: Biochemistry doi: 10.1021/bi901723p contributor: fullname: Bax – volume: 29 start-page: 739 year: 2008 end-page: 752 ident: CR49 article-title: Alpha-synuclein activates stress signaling protein kinases in THP-1 cells and microglia publication-title: Neurobiol Aging doi: 10.1016/j.neurobiolaging.2006.11.013 contributor: fullname: McGeer – volume: 8 start-page: 2804 year: 1988 end-page: 2815 ident: CR3 article-title: Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal publication-title: J Neurosci contributor: fullname: Scheller – volume: 18 start-page: 106 year: 1998 end-page: 108 ident: CR74 article-title: Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson’s disease publication-title: Nat Genet doi: 10.1038/ng0298-106 contributor: fullname: Riess – volume: 977 start-page: 493 year: 2002 end-page: 500 ident: CR15 article-title: Responses to donepezil in Alzheimer’s disease and Parkinson’s disease publication-title: Ann N Y Acad Sci doi: 10.1111/j.1749-6632.2002.tb04856.x contributor: fullname: Mori – volume: 395 start-page: 293 year: 1996 end-page: 298 ident: CR38 article-title: Phospholipase D is involved in cytosolic phospholipase A2-dependent selective release of arachidonic acid by fMLP-stimulated rat neutrophils publication-title: FEBS Lett doi: 10.1016/0014-5793(96)01056-3 contributor: fullname: Kudo – volume: 173 start-page: 2615 year: 2004 end-page: 2623 ident: CR22 article-title: Phospholipases D1 and D2 coordinately regulate macrophage phagocytosis publication-title: J Immunol contributor: fullname: Kusner – volume: 337 start-page: 1001 year: 2004 end-page: 1009 ident: CR25 article-title: Structural determinants of PLD2 inhibition by alpha-synuclein publication-title: J Mol Biol doi: 10.1016/j.jmb.2004.02.014 contributor: fullname: George – volume: 29 start-page: 1480 year: 2009 end-page: 1485 ident: CR63 article-title: Rab11a and HSP90 regulate recycling of extracellular alpha-synuclein publication-title: J Neurosci doi: 10.1523/JNEUROSCI.6202-08.2009 contributor: fullname: Zhang – volume: 105 start-page: 145 year: 2008 end-page: 150 ident: CR2 article-title: The Parkinson’s disease protein alpha-synuclein disrupts cellular Rab homeostasis publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0710685105 contributor: fullname: Lindquist – volume: 4 start-page: 2 year: 2007 ident: CR51 article-title: Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated alpha-synuclein publication-title: J Neuroinflammation doi: 10.1186/1742-2094-4-2 contributor: fullname: Zhang – volume: 180 start-page: 6027 year: 2008 end-page: 6034 ident: CR20 article-title: Phospholipase D1 plays a key role in TNF-alpha signaling publication-title: J Immunol contributor: fullname: Melendez – volume: 279 start-page: 14456 year: 2004 end-page: 14463 ident: CR29 article-title: Amyloid precursor protein mediates proinflammatory activation of monocytic lineage cells publication-title: J Biol Chem doi: 10.1074/jbc.M313747200 contributor: fullname: Combs – volume: 75 start-page: 1053 year: 2000 end-page: 1059 ident: CR40 article-title: Phospholipase D2 activity suppresses hydrogen peroxide-induced apoptosis in PC12 cells publication-title: J Neurochem doi: 10.1046/j.1471-4159.2000.0751053.x contributor: fullname: Ryu – volume: 280 start-page: 29194 year: 2005 end-page: 29198 ident: CR6 article-title: Superoxide dismutase/catalase mimetics are neuroprotective against selective paraquat-mediated dopaminergic neuron death in the substantial nigra: implications for Parkinson disease publication-title: J Biol Chem doi: 10.1074/jbc.M500984200 contributor: fullname: Andersen – volume: 45 start-page: 6956 year: 2006 end-page: 6966 ident: CR34 article-title: Acyl-CoA synthetase activity links wild-type but not mutant alpha-synuclein to brain arachidonate metabolism publication-title: Biochemistry doi: 10.1021/bi0600289 contributor: fullname: Murphy – volume: 275 start-page: 34393 year: 2000 end-page: 34398 ident: CR37 article-title: Interaction of human alpha-Synuclein and Parkinson’s disease variants with phospholipids. Structural analysis using site-directed mutagenesis publication-title: J Biol Chem doi: 10.1074/jbc.M004851200 contributor: fullname: George – volume: 1 start-page: 187 year: 2000 end-page: 198 ident: CR62 article-title: Three ways to make a vesicle publication-title: Nat Rev Mol Cell Biol doi: 10.1038/35043117 contributor: fullname: Kirchhausen – volume: 93 start-page: 1524 year: 2005 end-page: 1532 ident: CR7 article-title: DJ-1 is present in a large molecular complex in human brain tissue and interacts with alpha-synuclein publication-title: J Neurochem doi: 10.1111/j.1471-4159.2005.03145.x contributor: fullname: Giasson – volume: 182 start-page: 4137 year: 2009 end-page: 4149 ident: CR45 article-title: Nitrated {alpha}-synuclein-induced alterations in microglial immunity are regulated by CD4+ T cell subsets publication-title: J Immunol doi: 10.4049/jimmunol.0803982 contributor: fullname: Gendelman – volume: 55 start-page: 1178 year: 2007 end-page: 1188 ident: CR48 article-title: Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein publication-title: Glia doi: 10.1002/glia.20532 contributor: fullname: Zhang – volume: 26 start-page: 10558 year: 2006 end-page: 10563 ident: CR17 article-title: Alpha-synuclein expression modulates microglial activation phenotype publication-title: J Neurosci doi: 10.1523/JNEUROSCI.1799-06.2006 contributor: fullname: Combs – volume: 101 start-page: 201 year: 2007 end-page: 211 ident: CR33 article-title: Alpha-synuclein gene ablation increases docosahexaenoic acid incorporation and turnover in brain phospholipids publication-title: J Neurochem doi: 10.1111/j.1471-4159.2006.04357.x contributor: fullname: Murphy – volume: 2 start-page: 461 year: 2003 end-page: 462 ident: CR53 article-title: Soluble oligomers for the diagnosis of neurodegenerative diseases publication-title: Lancet Neurol doi: 10.1016/S1474-4422(03)00481-2 contributor: fullname: Allsop – volume: 432 start-page: 243 year: 2008 end-page: 247 ident: CR12 article-title: Brain prostaglandin formation is increased by alpha-synuclein gene-ablation during global ischemia publication-title: Neurosci Lett doi: 10.1016/j.neulet.2007.12.031 contributor: fullname: Murphy – volume: 322 start-page: 353 issue: Pt 2 year: 1997 end-page: 363 ident: CR39 article-title: Induction of cytosolic phospholipase A2 activity by phosphatidic acid and diglycerides in permeabilized human neutrophils: interrelationship between phospholipases D and A2 publication-title: Biochem J contributor: fullname: Wooten – volume: 21 start-page: 1179 year: 2001 end-page: 1188 ident: CR42 article-title: beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis publication-title: J Neurosci contributor: fullname: Landreth – volume: 26 start-page: 11915 year: 2006 end-page: 11922 ident: CR1 article-title: Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis publication-title: J Neurosci doi: 10.1523/JNEUROSCI.3821-06.2006 contributor: fullname: Sulzer – volume: 109 start-page: 1483 year: 2009 end-page: 1496 ident: CR18 article-title: Alpha-synuclein induces migration of BV-2 microglial cells by up-regulation of CD44 and MT1-MMP publication-title: J Neurochem doi: 10.1111/j.1471-4159.2009.06075.x contributor: fullname: Suh – volume: 7 start-page: 22 year: 2010 ident: CR28 article-title: Adhesion of monocytes to type I collagen stimulates an APP-dependent proinflammatory signaling response and release of Abeta1–40 publication-title: J Neuroinflammation doi: 10.1186/1742-2094-7-22 contributor: fullname: Combs – volume: 31 start-page: 1854 year: 2008 end-page: 1866 ident: CR30 article-title: Amyloid precursor protein mediates monocyte adhesion in AD tissue and apoE(−)/(−) mice publication-title: Neurobiol Aging doi: 10.1016/j.neurobiolaging.2008.10.013 contributor: fullname: Combs – volume: 5 start-page: e8784 year: 2010 ident: CR52 article-title: Microglia acquire distinct activation profiles depending on the degree of alpha-synuclein neuropathology in a rAAV based model of Parkinson’s disease publication-title: PLoS One doi: 10.1371/journal.pone.0008784 contributor: fullname: Romero-Ramos – volume: 8 start-page: 277 year: 2009 end-page: 284 ident: CR68 article-title: Possible roles of microglial cells for neurotoxicity in clinical neurodegenerative diseases and experimental animal models publication-title: Inflamm Allergy Drug Targets doi: 10.2174/187152809789352249 contributor: fullname: Kitani – volume: 218 start-page: 155 year: 2003 end-page: 176 ident: CR60 article-title: Measurements of phospholipases A2, C, and D (PLA2, PLC, and PLD). In vitro microassays, analysis of enzyme isoforms, and intact-cell assays publication-title: Methods Mol Biol contributor: fullname: Sha’afi – volume: 7 start-page: 365 year: 2006 end-page: 377 ident: CR59 article-title: Dynamics and function of phospholipase D and phosphatidic acid during phagocytosis publication-title: Traffic doi: 10.1111/j.1600-0854.2006.00389.x contributor: fullname: Grant – volume: 9 start-page: 934 year: 1997 end-page: 940 ident: CR64 article-title: Up-regulation of cyclooxygenase-2 expression in cultured microglia by prostaglandin E2, cyclic AMP and non-steroidal anti-inflammatory drugs publication-title: Eur J Neurosci doi: 10.1111/j.1460-9568.1997.tb01444.x contributor: fullname: Levi – volume: 62 start-page: 9 year: 2000 end-page: 14 ident: CR14 article-title: alpha-Synuclein is developmentally expressed in cultured rat brain oligodendrocytes publication-title: J Neurosci Res doi: 10.1002/1097-4547(20001001)62:1<9::AID-JNR2>3.0.CO;2-U contributor: fullname: Lee – volume: 277 start-page: 12334 year: 2002 end-page: 12342 ident: CR5 article-title: alpha-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells publication-title: J Biol Chem doi: 10.1074/jbc.M110414200 contributor: fullname: Min – volume: 20 start-page: 2000 year: 2006 end-page: 2008 ident: CR50 article-title: Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells publication-title: FASEB J doi: 10.1096/fj.06-6183com contributor: fullname: McGeer – volume: 276 start-page: 2045 year: 1997 end-page: 2047 ident: CR73 article-title: Mutation in the alpha-synuclein gene identified in families with Parkinson’s disease publication-title: Science doi: 10.1126/science.276.5321.2045 contributor: fullname: Nussbaum – volume: 37 start-page: 4901 year: 1998 end-page: 4909 ident: CR23 article-title: Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins publication-title: Biochemistry doi: 10.1021/bi972776r contributor: fullname: Morris – volume: 5 start-page: 121 year: 2004 end-page: 132 ident: CR61 article-title: Endocytic recycling publication-title: Nat Rev Mol Cell Biol doi: 10.1038/nrm1315 contributor: fullname: McGraw – volume: 302 start-page: 841 year: 2003 ident: CR75 article-title: alpha-Synuclein locus triplication causes Parkinson’s disease publication-title: Science doi: 10.1126/science.1090278 contributor: fullname: Gwinn-Hardy – volume: 19 start-page: 533 year: 2005 end-page: 542 ident: CR47 article-title: Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson’s disease publication-title: Faseb J doi: 10.1096/fj.04-2751com contributor: fullname: Zhang – volume: 44 start-page: 8251 year: 2005 end-page: 8259 ident: CR10 article-title: Alpha-synuclein gene deletion decreases brain palmitate uptake and alters the palmitate metabolism in the absence of alpha-synuclein palmitate binding publication-title: Biochemistry doi: 10.1021/bi0502137 contributor: fullname: Murphy – volume: 1781 start-page: 263 year: 2008 end-page: 269 ident: CR41 article-title: Potential role of phospholipase D2 in increasing interleukin-2 production by T-lymphocytes through activation of mitogen-activated protein kinases ERK1/ERK2 publication-title: Biochim Biophys Acta contributor: fullname: Record – volume: 29 start-page: 1690 year: 2008 end-page: 1701 ident: CR46 article-title: Synuclein activates microglia in a model of Parkinson’s disease publication-title: Neurobiol Aging doi: 10.1016/j.neurobiolaging.2007.04.006 contributor: fullname: Federoff – volume: 1323 start-page: 11 year: 2010 end-page: 17 ident: CR65 article-title: Prostaglandin E(2) reduces amyloid beta-induced phagocytosis in cultured rat microglia publication-title: Brain Res doi: 10.1016/j.brainres.2010.01.086 contributor: fullname: Takemura – volume: 1 start-page: 1375 year: 2001 end-page: 1384 ident: CR19 article-title: Phosphatidylcholine-specific phospholipase C and D in stimulation of RAW264.7 mouse macrophage-like cells by lipopolysaccharide publication-title: Int Immunopharmacol doi: 10.1016/S1567-5769(01)00069-8 contributor: fullname: Dong – volume: 100 start-page: 1407 year: 2007 end-page: 1420 ident: CR27 article-title: Tumor necrosis factor alpha stimulates NMDA receptor activity in mouse cortical neurons resulting in ERK-dependent death publication-title: J Neurochem doi: 10.1111/j.1471-4159.2006.04330.x contributor: fullname: Combs – volume: 279 start-page: 14456 year: 2004 ident: 439_CR29 publication-title: J Biol Chem doi: 10.1074/jbc.M313747200 contributor: fullname: CM Sondag – volume: 7 start-page: 22 year: 2010 ident: 439_CR28 publication-title: J Neuroinflammation doi: 10.1186/1742-2094-7-22 contributor: fullname: CM Sondag – volume: 101 start-page: 201 year: 2007 ident: 439_CR33 publication-title: J Neurochem doi: 10.1111/j.1471-4159.2006.04357.x contributor: fullname: MY Golovko – volume: 55 start-page: 1178 year: 2007 ident: 439_CR48 publication-title: Glia doi: 10.1002/glia.20532 contributor: fullname: W Zhang – volume: 1 start-page: 187 year: 2000 ident: 439_CR62 publication-title: Nat Rev Mol Cell Biol doi: 10.1038/35043117 contributor: fullname: T Kirchhausen – volume: 977 start-page: 493 year: 2002 ident: 439_CR15 publication-title: Ann N Y Acad Sci doi: 10.1111/j.1749-6632.2002.tb04856.x contributor: fullname: S Mori – volume: 22 start-page: 8797 year: 2002 ident: 439_CR26 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.22-20-08797.2002 contributor: fullname: DE Cabin – volume: 8 start-page: 277 year: 2009 ident: 439_CR68 publication-title: Inflamm Allergy Drug Targets doi: 10.2174/187152809789352249 contributor: fullname: S Sugama – volume: 8 start-page: 2804 year: 1988 ident: 439_CR3 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.08-08-02804.1988 contributor: fullname: L Maroteaux – volume: 10 start-page: S3 issue: Suppl 1 year: 2004 ident: 439_CR70 publication-title: Parkinsonism Relat Disord doi: 10.1016/j.parkreldis.2004.01.005 contributor: fullname: PL McGeer – volume: 318 start-page: 149 year: 2004 ident: 439_CR71 publication-title: Cell Tissue Res doi: 10.1007/s00441-004-0944-0 contributor: fullname: P Teismann – volume: 302 start-page: 1772 year: 2003 ident: 439_CR24 publication-title: Science doi: 10.1126/science.1090439 contributor: fullname: TF Outeiro – volume: 29 start-page: 739 year: 2008 ident: 439_CR49 publication-title: Neurobiol Aging doi: 10.1016/j.neurobiolaging.2006.11.013 contributor: fullname: A Klegeris – volume: 182 start-page: 4137 year: 2009 ident: 439_CR45 publication-title: J Immunol doi: 10.4049/jimmunol.0803982 contributor: fullname: AD Reynolds – volume: 1781 start-page: 263 year: 2008 ident: 439_CR41 publication-title: Biochim Biophys Acta doi: 10.1016/j.bbalip.2008.03.005 contributor: fullname: SM Hamdi – volume: 218 start-page: 155 year: 2003 ident: 439_CR60 publication-title: Methods Mol Biol contributor: fullname: J Gomez-Cambronero – volume: 216 start-page: 32 year: 2009 ident: 439_CR67 publication-title: J Neuroimmunol doi: 10.1016/j.jneuroim.2009.09.004 contributor: fullname: X Yang – volume: 622 start-page: 17 year: 1993 ident: 439_CR4 publication-title: Brain Res doi: 10.1016/0006-8993(93)90796-P contributor: fullname: T Shibayama-Imazu – volume: 31 start-page: 1854 year: 2008 ident: 439_CR30 publication-title: Neurobiol Aging doi: 10.1016/j.neurobiolaging.2008.10.013 contributor: fullname: SA Austin – volume: 432 start-page: 243 year: 2008 ident: 439_CR12 publication-title: Neurosci Lett doi: 10.1016/j.neulet.2007.12.031 contributor: fullname: MY Golovko – volume: 94 start-page: 839 year: 2005 ident: 439_CR9 publication-title: J Neurochem doi: 10.1111/j.1471-4159.2005.03247.x contributor: fullname: PI Castagnet – volume: 5 start-page: 121 year: 2004 ident: 439_CR61 publication-title: Nat Rev Mol Cell Biol doi: 10.1038/nrm1315 contributor: fullname: FR Maxfield – volume: 20 start-page: 3214 year: 2000 ident: 439_CR8 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.20-09-03214.2000 contributor: fullname: DD Murphy – volume: 180 start-page: 6027 year: 2008 ident: 439_CR20 publication-title: J Immunol doi: 10.4049/jimmunol.180.9.6027 contributor: fullname: S Sethu – volume: 109 start-page: 1483 year: 2009 ident: 439_CR18 publication-title: J Neurochem doi: 10.1111/j.1471-4159.2009.06075.x contributor: fullname: S Kim – volume: 146 start-page: 139 year: 2004 ident: 439_CR16 publication-title: Toxicol Lett doi: 10.1016/j.toxlet.2003.09.009 contributor: fullname: SY Cheng – volume: 25 start-page: 6016 year: 2005 ident: 439_CR54 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.0692-05.2005 contributor: fullname: HJ Lee – volume: 1 start-page: 1375 year: 2001 ident: 439_CR19 publication-title: Int Immunopharmacol doi: 10.1016/S1567-5769(01)00069-8 contributor: fullname: F Zhang – volume: 20 start-page: 2000 year: 2006 ident: 439_CR50 publication-title: FASEB J doi: 10.1096/fj.06-6183com contributor: fullname: A Klegeris – volume: 29 start-page: 1480 year: 2009 ident: 439_CR63 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.6202-08.2009 contributor: fullname: J Liu – volume: 2 start-page: 461 year: 2003 ident: 439_CR53 publication-title: Lancet Neurol doi: 10.1016/S1474-4422(03)00481-2 contributor: fullname: OM El-Agnaf – volume: 337 start-page: 1001 year: 2004 ident: 439_CR25 publication-title: J Mol Biol doi: 10.1016/j.jmb.2004.02.014 contributor: fullname: JE Payton – volume: 275 start-page: 34393 year: 2000 ident: 439_CR37 publication-title: J Biol Chem doi: 10.1074/jbc.M004851200 contributor: fullname: RJ Perrin – volume: 75 start-page: 1053 year: 2000 ident: 439_CR40 publication-title: J Neurochem doi: 10.1046/j.1471-4159.2000.0751053.x contributor: fullname: SD Lee – volume: 37 start-page: 4901 year: 1998 ident: 439_CR23 publication-title: Biochemistry doi: 10.1021/bi972776r contributor: fullname: JM Jenco – volume: 322 start-page: 353 issue: Pt 2 year: 1997 ident: 439_CR39 publication-title: Biochem J doi: 10.1042/bj3220353 contributor: fullname: SA Bauldry – volume: 5 start-page: e8784 year: 2010 ident: 439_CR52 publication-title: PLoS One doi: 10.1371/journal.pone.0008784 contributor: fullname: V Sanchez-Guajardo – volume: 100 start-page: 1407 year: 2007 ident: 439_CR27 publication-title: J Neurochem doi: 10.1111/j.1471-4159.2006.04330.x contributor: fullname: JH Jara – volume: 49 start-page: 893 year: 2008 ident: 439_CR31 publication-title: J Lipid Res doi: 10.1194/jlr.D700030-JLR200 contributor: fullname: MY Golovko – volume: 277 start-page: 12334 year: 2002 ident: 439_CR5 publication-title: J Biol Chem doi: 10.1074/jbc.M110414200 contributor: fullname: BH Ahn – volume: 326 start-page: 55 year: 2009 ident: 439_CR11 publication-title: Mol Cell Biochem doi: 10.1007/s11010-008-0008-y contributor: fullname: MY Golovko – volume: 48 start-page: 2304 year: 2009 ident: 439_CR36 publication-title: Biochemistry doi: 10.1021/bi900114z contributor: fullname: AJ Trexler – volume: 26 start-page: 10558 year: 2006 ident: 439_CR17 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.1799-06.2006 contributor: fullname: SA Austin – volume: 381 start-page: 39 year: 2009 ident: 439_CR44 publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2009.02.002 contributor: fullname: SB Lee – volume: 276 start-page: 2045 year: 1997 ident: 439_CR73 publication-title: Science doi: 10.1126/science.276.5321.2045 contributor: fullname: MH Polymeropoulos – volume: 302 start-page: 841 year: 2003 ident: 439_CR75 publication-title: Science doi: 10.1126/science.1090278 contributor: fullname: AB Singleton – volume: 280 start-page: 29194 year: 2005 ident: 439_CR6 publication-title: J Biol Chem doi: 10.1074/jbc.M500984200 contributor: fullname: J Peng – volume: 62 start-page: 9 year: 2000 ident: 439_CR14 publication-title: J Neurosci Res doi: 10.1002/1097-4547(20001001)62:1<9::AID-JNR2>3.0.CO;2-U contributor: fullname: C Richter-Landsberg – volume: 4 start-page: 2 year: 2007 ident: 439_CR51 publication-title: J Neuroinflammation doi: 10.1186/1742-2094-4-2 contributor: fullname: J Jin – volume: 281 start-page: 32148 year: 2006 ident: 439_CR13 publication-title: J Biol Chem doi: 10.1074/jbc.M605965200 contributor: fullname: S Wislet-Gendebien – volume: 93 start-page: 1524 year: 2005 ident: 439_CR7 publication-title: J Neurochem doi: 10.1111/j.1471-4159.2005.03145.x contributor: fullname: MC Meulener – volume: 45 start-page: 6956 year: 2006 ident: 439_CR34 publication-title: Biochemistry doi: 10.1021/bi0600289 contributor: fullname: MY Golovko – volume: 79 start-page: 596 year: 2010 ident: 439_CR69 publication-title: Biochem Pharmacol doi: 10.1016/j.bcp.2009.09.026 contributor: fullname: J Ock – volume: 18 start-page: 106 year: 1998 ident: 439_CR74 publication-title: Nat Genet doi: 10.1038/ng0298-106 contributor: fullname: R Kruger – volume: 395 start-page: 293 year: 1996 ident: 439_CR38 publication-title: FEBS Lett doi: 10.1016/0014-5793(96)01056-3 contributor: fullname: K Fujita – volume: 45 start-page: 3386 year: 2006 ident: 439_CR56 publication-title: Biochemistry doi: 10.1021/bi052344d contributor: fullname: M Ramakrishnan – volume: 26 start-page: 11915 year: 2006 ident: 439_CR1 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.3821-06.2006 contributor: fullname: KE Larsen – volume: 212 start-page: 491 year: 1993 ident: 439_CR21 publication-title: Eur J Biochem doi: 10.1111/j.1432-1033.1993.tb17686.x contributor: fullname: D Valck De – volume: 9 start-page: 934 year: 1997 ident: 439_CR64 publication-title: Eur J Neurosci doi: 10.1111/j.1460-9568.1997.tb01444.x contributor: fullname: L Minghetti – volume: 19 start-page: 533 year: 2005 ident: 439_CR47 publication-title: Faseb J doi: 10.1096/fj.04-2751com contributor: fullname: W Zhang – volume: 2 start-page: 14 year: 2005 ident: 439_CR72 publication-title: J Neuroinflammation doi: 10.1186/1742-2094-2-14 contributor: fullname: E Croisier – volume: 105 start-page: 145 year: 2008 ident: 439_CR2 publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0710685105 contributor: fullname: AD Gitler – volume: 29 start-page: 1690 year: 2008 ident: 439_CR46 publication-title: Neurobiol Aging doi: 10.1016/j.neurobiolaging.2007.04.006 contributor: fullname: X Su – volume: 4 start-page: 419 year: 2009 ident: 439_CR55 publication-title: J Neuroimmune Pharmacol doi: 10.1007/s11481-009-9176-0 contributor: fullname: JK Lee – volume: 358 start-page: 119 year: 2001 ident: 439_CR57 publication-title: Biochem J doi: 10.1042/0264-6021:3580119 contributor: fullname: M Locati – volume: 10 start-page: 218 year: 2009 ident: 439_CR66 publication-title: Traffic doi: 10.1111/j.1600-0854.2008.00853.x contributor: fullname: T Ben Gedalya – volume: 7 start-page: 365 year: 2006 ident: 439_CR59 publication-title: Traffic doi: 10.1111/j.1600-0854.2006.00389.x contributor: fullname: M Corrotte – volume: 173 start-page: 2615 year: 2004 ident: 439_CR22 publication-title: J Immunol doi: 10.4049/jimmunol.173.4.2615 contributor: fullname: SS Iyer – volume: 1323 start-page: 11 year: 2010 ident: 439_CR65 publication-title: Brain Res doi: 10.1016/j.brainres.2010.01.086 contributor: fullname: T Nagano – volume: 163 start-page: 5462 year: 1999 ident: 439_CR58 publication-title: J Immunol doi: 10.4049/jimmunol.163.10.5462 contributor: fullname: JH Kim – volume: 44 start-page: 8251 year: 2005 ident: 439_CR10 publication-title: Biochemistry doi: 10.1021/bi0502137 contributor: fullname: MY Golovko – volume: 101 start-page: 132 year: 2007 ident: 439_CR32 publication-title: J Neurochem doi: 10.1111/j.1471-4159.2006.04348.x contributor: fullname: G Barcelo-Coblijn – volume: 49 start-page: 862 year: 2010 ident: 439_CR35 publication-title: Biochemistry doi: 10.1021/bi901723p contributor: fullname: CR Bodner – volume: 22 start-page: 897 year: 2009 ident: 439_CR43 publication-title: Int J Immunopathol Pharmacol doi: 10.1177/039463200902200405 contributor: fullname: H Wilms – volume: 21 start-page: 1179 year: 2001 ident: 439_CR42 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.21-04-01179.2001 contributor: fullname: CK Combs |
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| Snippet | Alpha (α)-synuclein neuronal effects are continually being defined although its role in regulating glial phenotypes remains unclear. An ability to regulate... |
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| SubjectTerms | alpha-Synuclein - genetics alpha-Synuclein - physiology Animals Biochemistry Biomedical and Life Sciences Biomedicine Blotting, Western Cell Biology Mice Mice, Knockout Microglia - physiology Neurochemistry Neurology Neurosciences Original Paper |
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| Title | Lack of Alpha-Synuclein Modulates Microglial Phenotype In Vitro |
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