Reversal of dietary-induced insulin resistance in muscle of the rat by adenosine deaminase and an adenosine-receptor antagonist

Transfer of young rats from a maintenance diet to a breeding diet plus 10% sucrose in the drinking water for 4 weeks caused the development of insulin resistance. Inclusion of the enzyme adenosine deaminase or the adenosine-receptor antagonist 8-phenyltheophylline caused a marked increase in the sen...

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Bibliographic Details
Published inBiochemical journal Vol. 224; no. 1; pp. 327 - 330
Main Authors Budohoski, L, Challiss, R A, Cooney, G J, McManus, B, Newsholme, E A
Format Journal Article
LanguageEnglish
Published England 15.11.1984
Subjects
Adenosine Deaminase - pharmacology
Animals
Dietary Carbohydrates - pharmacology
Glycogen - biosynthesis
Insulin - pharmacology
Insulin Resistance
Lactates - metabolism
Lactic Acid
Male
Muscles - drug effects
Muscles - metabolism
Nucleoside Deaminases - pharmacology
Rats
Rats, Inbred Strains
Sucrose - pharmacology
Theophylline - analogs & derivatives
Theophylline - pharmacology
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Summary:Transfer of young rats from a maintenance diet to a breeding diet plus 10% sucrose in the drinking water for 4 weeks caused the development of insulin resistance. Inclusion of the enzyme adenosine deaminase or the adenosine-receptor antagonist 8-phenyltheophylline caused a marked increase in the sensitivity of the soleus-muscle strips isolated from the diet-induced insulin-resistant rats: the concentration of insulin giving 50% of maximum response of glycolysis shifted from 500 to less than 20 microunits/ml.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0264-6021
1470-8728
DOI:10.1042/bj2240327