Kaposi's sarcoma in women with AIDS

• Published in: AIDS (London) Vol. 10; no. 11; p. 1221
• Main Authors: Cooley, T P, Hirschhorn, L R, O'Keane, J C
• Format: Journal Article
• Language: English
• Published: England 01.09.1996
• Subjects: Acquired Immunodeficiency Syndrome - complications; Adult; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Cohort Studies; Female; Humans; Incidence; Male; Middle Aged; Retrospective Studies; Sarcoma, Kaposi - complications; Sarcoma, Kaposi - drug therapy; Sarcoma, Kaposi - epidemiology; Sarcoma, Kaposi - physiopathology; Sex Factors; Sexual Behavior
• ISSN: 0269-9370
• DOI: 10.1097/00002030-199609000-00007

To describe the presentation and incidence of Kaposi's sarcoma (KS) in a cohort of women infected with HIV and to compare their clinical characteristics with men at the same institution. Retrospective chart and database review. Adult clinical AIDS program outpatient clinics at a municipal teaching hospital. One hundred and seven people with KS were found of whom twelve (11.2%) were women. The prevalence of KS in women was 3.6% compared with 9.9% among men (P < 0.001). Women born outside the United States were at increased risk of developing KS (P < 0.05). At initial KS presentation, no difference in HIV stage or CD4 count was found between men and women. Women presented with more advanced KS than men, with increased incidence of non-cutaneous disease (P < 0.001), lymphedema (P < 0.0001), lymph-node disease (P < 0.0001) and visceral disease (P = 0.03). Women had decreased survival after KS diagnosis compared to men, although the difference was not significant (P = 0.41). KS is not a rare diagnosis in HIV-infected women followed at our institution. Although the increased risk of KS in men is most likely to be related to differences in exposure, the sex-related differences in presentation and course may be due in part to delay in diagnosis. KS should be considered in the spectrum of HIV-related complications in women as well as in men.