Refined mapping of the three DNA repair genes, ERCC1, ERCC2, and XRCC1, on human chromosome 19

Three DNA repair genes, ERCC1, ERCC2, and XRCC1, have been regionally mapped on human chromosome 19. ERCC2 and XRCC1 have been assigned to bands q13.2---q13.3 by in situ hybridization using fluorescently-labeled cosmid probes. ERCC1 and ERCC2 have been found to be separated by less than 250 kb by la...

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Bibliographic Details
Published inCytogenetics and cell genetics Vol. 52; no. 1-2; p. 11
Main Authors Mohrenweiser, H W, Carrano, A V, Fertitta, A, Perry, B, Thompson, L H, Tucker, J D, Weber, C A
Format Journal Article
LanguageEnglish
Published Switzerland 1989
Subjects
Blotting, Southern
Chromosome Mapping
Chromosomes, Human, Pair 19
DNA
DNA Probes
DNA Repair - genetics
DNA Restriction Enzymes
Electrophoresis, Agar Gel
Female
Genetic Linkage
Humans
Nucleic Acid Hybridization
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Summary:Three DNA repair genes, ERCC1, ERCC2, and XRCC1, have been regionally mapped on human chromosome 19. ERCC2 and XRCC1 have been assigned to bands q13.2---q13.3 by in situ hybridization using fluorescently-labeled cosmid probes. ERCC1 and ERCC2 have been found to be separated by less than 250 kb by large fragment restriction enzyme site mapping.
ISSN:0301-0171
DOI:10.1159/000132829