Chronic Toxicity of Erythromycin Thiocyanate to Daphnia magna in a Flow-Through, Continuous Exposure Test System

• Published in: Bulletin of environmental contamination and toxicology Vol. 87; no. 6; pp. 621 - 625
• Main Authors: Meinertz, Jeffery R., Schreier, Theresa M., Bernardy, Jeffry A.
• Format: Journal Article
• Language: English
• Published: New York Springer-Verlag 01.12.2011; Springer Nature B.V
• Subjects: Animal diseases; Animals; Antibiotics; Aquatic Pollution; Crustaceans; Daphnia - drug effects; Dose-Response Relationship, Drug; Earth and Environmental Science; Ecotoxicology; Environment; Environmental Chemistry; Environmental Health; Environmental impact; Environmental Monitoring - methods; Erythromycin - analogs & derivatives; Erythromycin - toxicity; Fresh Water - chemistry; Pollution; Reproduction - drug effects; Soil Science & Conservation; Toxicity; Toxicity Tests, Chronic - methods; Waste Water Technology; Water Management; Water Pollutants, Chemical - toxicity; Water Pollution Control; Assessing the environmental impact of an aquaculture drug; Toxicity of erythromycin thiocyanate to
• ISSN: 0007-4861; 1432-0800
• DOI: 10.1007/s00128-011-0415-8

Approval of a new animal drug application for AQUAMYCIN 100 ® (erythromycin thiocyanate; ET) to treat freshwater salmonid species with bacterial kidney disease is being pursued in the US. As part of the approval process, ET’s impact on an aquatic environment had to be described in an environmental assessment. The environmental assessment was lacking data to characterize the effect ET would have on a chronically exposed aquatic invertebrate organism. A major step to fulfilling the environmental assessment was completed after conducting a comprehensive study continuously exposing Daphnia magna to ET for 21 days. Results indicated that the no observable effect concentration for ET was 179 μg/L.