Effect of inositol and tri-iodothyronine on the hormonal responsiveness of hepatocytes obtained from partially hepatectomized rats

Hepatocytes obtained from animals partially hepatectomized (72 h before the experiment) have a diminished responsiveness to alpha 1-adrenergic amines, vasopressin, angiotensin and glucagon and an increased responsiveness to beta-adrenergic amines. Administration of inositol or tri-iodothyronine to t...

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Published inBiochemical journal Vol. 223; no. 3; pp. 925 - 928
Main Authors Huerta-Bahena, J, García-Sáinz, J A
Format Journal Article
LanguageEnglish
Published England 01.11.1984
Subjects
Angiotensin II - pharmacology
Animals
Arginine Vasopressin - pharmacology
Epinephrine - pharmacology
Female
Glucagon - pharmacology
Hepatectomy
In Vitro Techniques
Inositol - pharmacology
Isoproterenol - pharmacology
Liver - cytology
Liver - drug effects
Liver - metabolism
Propranolol - pharmacology
Rats
Rats, Inbred Strains
Triiodothyronine - pharmacology
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Summary:Hepatocytes obtained from animals partially hepatectomized (72 h before the experiment) have a diminished responsiveness to alpha 1-adrenergic amines, vasopressin, angiotensin and glucagon and an increased responsiveness to beta-adrenergic amines. Administration of inositol or tri-iodothyronine to the hepatectomized animals induced a recovery in the hepatocyte responsiveness to the Ca2+-dependent hormones and abolished that to beta-adrenergic amines; the response to glucagon was not improved.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0264-6021
1470-8728
DOI:10.1042/bj2230925