Manganese as a potential marker of atherogenesis

• Published in: Doklady. Biochemistry and biophysics Vol. 434; no. 1; pp. 254 - 256
• Main Authors: Lozhkin, A. P., Biktagirov, T. B., Abdul’yanov, V. A., Voloshin, A. V., Silkin, N. I., Khairullin, R. N., Salakhov, M. Kh, Ilinskaya, O. N.
• Format: Journal Article
• Language: English
• Published: Dordrecht SP MAIK Nauka/Interperiodica 01.10.2010; Springer Nature B.V
• Subjects: Aorta - metabolism; Atherosclerosis; Atherosclerosis - metabolism; Biochemistry; Biological and Medical Physics; Biomarkers - metabolism; Biomedical and Life Sciences; Biophysics; Biophysics and Molecular Biology; Correlation analysis; Electron Spin Resonance Spectroscopy; Humans; Life Sciences; Manganese - metabolism; Mass spectrometry; Atherosclerotic Lesion; DOKLADY Biochemistry; Manganese Superoxide; Zinc Superoxide Dismutase; Zinc Superoxide
• ISSN: 1607-6729; 1608-3091
• DOI: 10.1134/S1607672910050091

Inductively coupled plasma mass spectrometry was used to assess the content of zinc, copper, iron, manganese, calcium, and phosphorus in samples of aorta walls with atherosclerotic lesions. New consistent patterns in the distribution of these elements depending on the level of pathological changes in the aorta, characterized by the degree of calcification (Ca/P ratio), were found. Correlation analysis showed that the relationship between the content of zinc and calcium, but not zinc and iron, is significant, which partially rejects the common idea on the antiatherogenic role of zinc. Significant negative correlation with the degree of calcification was found only for manganese. The results of this study allow this element to be considered as a potential marker of atherogenesis.