Regioselective ortho-lithiation of chloro and bromo substituted fluoroarenes

Deprotonation of fluoroarenes carrying chlorine or bromine as additional substitutents occurs always at a fluorine adjacent position if accomplished with potassium tert-butoxide activated butyllithium or lithium 2,2,6,6-tetramethylpiperidide. Graphic

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Bibliographic Details
Published inTetrahedron letters Vol. 37; no. 36; pp. 6551 - 6554
Main Authors Mongin, Florence, Schlosser, Manfred
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 02.09.1996
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
POSITION
FLUORINE
METALATION
BENZENES
SOLVENT
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Summary:Deprotonation of fluoroarenes carrying chlorine or bromine as additional substitutents occurs always at a fluorine adjacent position if accomplished with potassium tert-butoxide activated butyllithium or lithium 2,2,6,6-tetramethylpiperidide. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/0040-4039(96)01398-6