Bis-naphthalimides. 2. Synthesis and biological activity of 5,6-acenaphthalimidoalkyl-1,8-naphthalimidoalkyl amines

A series of non-symmetric bis-naphthalimides bearing a conveniently substituted 1,8-naphthalimide and a 5,6-acenaphthalimide chromophore was synthesized and in vitro activities were determined. Although previous studies suggested that the presence of the acenaphthalimide system in the structure enha...

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Published inEuropean journal of medicinal chemistry Vol. 30; no. 3; pp. 235 - 239
Main Authors Braña, MF, Castellano, JM, Morán, M, Pérez de Vega, MJ, Qian, XD, Romerdahl, CA, Keilhauer, G
Format Journal Article
LanguageEnglish
Published PARIS CEDEX 15 Elsevier Masson SAS 1995
Elsevier
Subjects
bis-intercalator
bis-naphthalimide
cancer
Chemistry, Medicinal
Life Sciences & Biomedicine
naphthalimide
Pharmacology & Pharmacy
Science & Technology
cancer
naphthalimide
bis-naphthalimide
bis-intercalator
BIS-INTERCALATOR
NAPHTHALIMIDE
BIS-NAPHTHALIMIDE
CANCER
DNA
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Summary:A series of non-symmetric bis-naphthalimides bearing a conveniently substituted 1,8-naphthalimide and a 5,6-acenaphthalimide chromophore was synthesized and in vitro activities were determined. Although previous studies suggested that the presence of the acenaphthalimide system in the structure enhances aqueous solubility, we found that these compounds were no more soluble or cytotoxic than the homologous symmetric series.
ISSN:0223-5234
1768-3254
DOI:10.1016/0223-5234(96)88230-4